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Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway
A large body of data has established the hypothalamic kisspeptin (KP) and its receptor, KISS1R, as major players in the activation of the neuroendocrine reproductive axis at the time of puberty and maintenance of reproductive capacity in the adult. Due to its strategic location, this ligand-receptor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882778/ https://www.ncbi.nlm.nih.gov/pubmed/29643834 http://dx.doi.org/10.3389/fendo.2018.00123 |
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author | Wahab, Fazal Atika, Bibi Ullah, Farhad Shahab, Muhammad Behr, Rüdiger |
author_facet | Wahab, Fazal Atika, Bibi Ullah, Farhad Shahab, Muhammad Behr, Rüdiger |
author_sort | Wahab, Fazal |
collection | PubMed |
description | A large body of data has established the hypothalamic kisspeptin (KP) and its receptor, KISS1R, as major players in the activation of the neuroendocrine reproductive axis at the time of puberty and maintenance of reproductive capacity in the adult. Due to its strategic location, this ligand-receptor pair acts as an integrator of cues from gonadal steroids as well as of circadian and seasonal variation-related information on the reproductive axis. Besides these cues, the activity of the hypothalamic KP signaling is very sensitive to the current metabolic status of the body. In conditions of energy imbalance, either positive or negative, a number of alterations in the hypothalamic KP signaling pathway have been documented in different mammalian models including nonhuman primates and human. Deficiency of metabolic fuels during fasting causes a marked reduction of Kiss1 gene transcript levels in the hypothalamus and, hence, decreases the output of KP-containing neurons. Food intake or exogenous supply of metabolic cues, such as leptin, reverses metabolic insufficiency-related changes in the hypothalamic KP signaling. Likewise, alterations in Kiss1 expression have also been reported in other situations of energy imbalance like diabetes and obesity. Information related to the body’s current metabolic status reaches to KP neurons both directly as well as indirectly via a complex network of other neurons. In this review article, we have provided an updated summary of the available literature on the regulation of the hypothalamic KP-Kiss1r signaling by metabolic cues. In particular, the potential mechanisms of metabolic impact on the hypothalamic KP-Kiss1r signaling, in light of available evidence, are discussed. |
format | Online Article Text |
id | pubmed-5882778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58827782018-04-11 Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway Wahab, Fazal Atika, Bibi Ullah, Farhad Shahab, Muhammad Behr, Rüdiger Front Endocrinol (Lausanne) Endocrinology A large body of data has established the hypothalamic kisspeptin (KP) and its receptor, KISS1R, as major players in the activation of the neuroendocrine reproductive axis at the time of puberty and maintenance of reproductive capacity in the adult. Due to its strategic location, this ligand-receptor pair acts as an integrator of cues from gonadal steroids as well as of circadian and seasonal variation-related information on the reproductive axis. Besides these cues, the activity of the hypothalamic KP signaling is very sensitive to the current metabolic status of the body. In conditions of energy imbalance, either positive or negative, a number of alterations in the hypothalamic KP signaling pathway have been documented in different mammalian models including nonhuman primates and human. Deficiency of metabolic fuels during fasting causes a marked reduction of Kiss1 gene transcript levels in the hypothalamus and, hence, decreases the output of KP-containing neurons. Food intake or exogenous supply of metabolic cues, such as leptin, reverses metabolic insufficiency-related changes in the hypothalamic KP signaling. Likewise, alterations in Kiss1 expression have also been reported in other situations of energy imbalance like diabetes and obesity. Information related to the body’s current metabolic status reaches to KP neurons both directly as well as indirectly via a complex network of other neurons. In this review article, we have provided an updated summary of the available literature on the regulation of the hypothalamic KP-Kiss1r signaling by metabolic cues. In particular, the potential mechanisms of metabolic impact on the hypothalamic KP-Kiss1r signaling, in light of available evidence, are discussed. Frontiers Media S.A. 2018-03-28 /pmc/articles/PMC5882778/ /pubmed/29643834 http://dx.doi.org/10.3389/fendo.2018.00123 Text en Copyright © 2018 Wahab, Atika, Ullah, Shahab and Behr. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Wahab, Fazal Atika, Bibi Ullah, Farhad Shahab, Muhammad Behr, Rüdiger Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway |
title | Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway |
title_full | Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway |
title_fullStr | Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway |
title_full_unstemmed | Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway |
title_short | Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway |
title_sort | metabolic impact on the hypothalamic kisspeptin-kiss1r signaling pathway |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882778/ https://www.ncbi.nlm.nih.gov/pubmed/29643834 http://dx.doi.org/10.3389/fendo.2018.00123 |
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