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Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression
The anti-inflammatory effect of omega 3 polyunsaturated fatty acids has been confirmed in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA) that has displayed strong anti-inflammatory effects in various inflammato...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882824/ https://www.ncbi.nlm.nih.gov/pubmed/29615641 http://dx.doi.org/10.1038/s41598-018-23623-9 |
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author | Saito-Sasaki, Natsuko Sawada, Yu Mashima, Emi Yamaguchi, Takashi Ohmori, Shun Yoshioka, Haruna Haruyama, Sanehito Okada, Etsuko Nakamura, Motonobu |
author_facet | Saito-Sasaki, Natsuko Sawada, Yu Mashima, Emi Yamaguchi, Takashi Ohmori, Shun Yoshioka, Haruna Haruyama, Sanehito Okada, Etsuko Nakamura, Motonobu |
author_sort | Saito-Sasaki, Natsuko |
collection | PubMed |
description | The anti-inflammatory effect of omega 3 polyunsaturated fatty acids has been confirmed in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA) that has displayed strong anti-inflammatory effects in various inflammatory disease models. However, the effect of topical MaR1 on cutaneous inflammation remains unclear. Therefore, we initially examined the anti-inflammatory effects of topical Maresin-1 using an imiquimod (IMQ)-induced psoriasis-like mouse model of inflammation. Topical MaR1 reduced the ear swelling response as seen in histological findings. RT-PCR and flow cytometry analyses revealed MaR1 had no inhibitory effect on IL-23, but MaR1 suppressed IL-17A production by γδTCR(mid+) and CD4(+) cells in the skin. These inhibitory effects were also observed in a subcutaneous IL-23-injected psoriasis model. MaR1 downmodulated IL-23 receptor (IL-23R) expression by suppressing retinoic acid-related orphan receptor γt (RORγt) expression and internalization in a clathrin-dependent manner in γδTCR(mid+) and CD4(+) cells. These results lead to assumptions that topical MaR1 may be a new therapeutic agent for psoriasis and other IL-17-mediated cutaneous inflammatory diseases. |
format | Online Article Text |
id | pubmed-5882824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58828242018-04-09 Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression Saito-Sasaki, Natsuko Sawada, Yu Mashima, Emi Yamaguchi, Takashi Ohmori, Shun Yoshioka, Haruna Haruyama, Sanehito Okada, Etsuko Nakamura, Motonobu Sci Rep Article The anti-inflammatory effect of omega 3 polyunsaturated fatty acids has been confirmed in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA) that has displayed strong anti-inflammatory effects in various inflammatory disease models. However, the effect of topical MaR1 on cutaneous inflammation remains unclear. Therefore, we initially examined the anti-inflammatory effects of topical Maresin-1 using an imiquimod (IMQ)-induced psoriasis-like mouse model of inflammation. Topical MaR1 reduced the ear swelling response as seen in histological findings. RT-PCR and flow cytometry analyses revealed MaR1 had no inhibitory effect on IL-23, but MaR1 suppressed IL-17A production by γδTCR(mid+) and CD4(+) cells in the skin. These inhibitory effects were also observed in a subcutaneous IL-23-injected psoriasis model. MaR1 downmodulated IL-23 receptor (IL-23R) expression by suppressing retinoic acid-related orphan receptor γt (RORγt) expression and internalization in a clathrin-dependent manner in γδTCR(mid+) and CD4(+) cells. These results lead to assumptions that topical MaR1 may be a new therapeutic agent for psoriasis and other IL-17-mediated cutaneous inflammatory diseases. Nature Publishing Group UK 2018-04-03 /pmc/articles/PMC5882824/ /pubmed/29615641 http://dx.doi.org/10.1038/s41598-018-23623-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Saito-Sasaki, Natsuko Sawada, Yu Mashima, Emi Yamaguchi, Takashi Ohmori, Shun Yoshioka, Haruna Haruyama, Sanehito Okada, Etsuko Nakamura, Motonobu Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression |
title | Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression |
title_full | Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression |
title_fullStr | Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression |
title_full_unstemmed | Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression |
title_short | Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression |
title_sort | maresin-1 suppresses imiquimod-induced skin inflammation by regulating il-23 receptor expression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882824/ https://www.ncbi.nlm.nih.gov/pubmed/29615641 http://dx.doi.org/10.1038/s41598-018-23623-9 |
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