Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation

Four CaMKII isoforms are encoded by distinct genes, and alternative splicing within the variable linker-region generates additional diversity. The α and β isoforms are largely brain-specific, where they mediate synaptic functions underlying learning, memory and cognition. Here, we determined the α a...

Descripción completa

Detalles Bibliográficos
Autores principales: Cook, Sarah G., Bourke, Ashley M., O’Leary, Heather, Zaegel, Vincent, Lasda, Erika, Mize-Berge, Janna, Quillinan, Nidia, Tucker, Chandra L., Coultrap, Steven J., Herson, Paco S., Bayer, K. Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882894/
https://www.ncbi.nlm.nih.gov/pubmed/29615706
http://dx.doi.org/10.1038/s41598-018-23779-4

Ejemplares similares

Ejemplares similares