Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy

T cell function can be compromised during chronic infections or through continuous exposure to tumor antigens by the action of immune checkpoint receptors, such as programmed cell death protein 1 (PD-1). Systemic administration of blocking antibodies against the PD-1 pathway can restore T cell funct...

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Detalles Bibliográficos
Autores principales: Zhang, Chi, Peng, Yanchun, Hublitz, Philip, Zhang, Haokang, Dong, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882910/
https://www.ncbi.nlm.nih.gov/pubmed/29615718
http://dx.doi.org/10.1038/s41598-018-23803-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882910/
https://www.ncbi.nlm.nih.gov/pubmed/29615718
http://dx.doi.org/10.1038/s41598-018-23803-7

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