Ribosome-dependent conformational flexibility changes and RNA dynamics of IRES domains revealed by differential SHAPE

Internal ribosome entry site (IRES) elements are RNA regions that recruit the translation machinery internally. Here we investigated the conformational changes and RNA dynamics of a picornavirus IRES upon incubation with distinct ribosomal fractions. Differential SHAPE analysis of the free RNA showe...

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Detalles Bibliográficos
Autores principales: Lozano, Gloria, Francisco-Velilla, Rosario, Martinez-Salas, Encarnacion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882922/
https://www.ncbi.nlm.nih.gov/pubmed/29615727
http://dx.doi.org/10.1038/s41598-018-23845-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882922/
https://www.ncbi.nlm.nih.gov/pubmed/29615727
http://dx.doi.org/10.1038/s41598-018-23845-x

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