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Idelalisib impairs TREM-1 mediated neutrophil inflammatory responses

Triggering receptor expressed on myeloid cells (TREM)-1 on polymorphonuclear neutrophils (PMN) regulates innate immune activation in infectious and non-infectious conditions. TREM-1 ligation activates phosphatidyl-inositol 3 kinase (PI3K) triggering all neutrophil effector functions. As idelalisib i...

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Detalles Bibliográficos
Autores principales:	Alflen, Astrid, Stadler, Nicole, Aranda Lopez, Pamela, Teschner, Daniel, Theobald, Matthias, Heß, Georg, Radsak, Markus P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882939/ https://www.ncbi.nlm.nih.gov/pubmed/29615799 http://dx.doi.org/10.1038/s41598-018-23808-2

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