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Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region

Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge about the population characteristics influencing the dispersal of parasite speci...

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Autores principales: Camargo, Milena, Soto-De León, Sara C., Del Río-Ospina, Luisa, Páez, Astrid C., González, Zanony, González, Edgardo, Cubides, Juan R., Camargo-Ayala, Paola A., Patarroyo, Manuel E., Patarroyo, Manuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883018/
https://www.ncbi.nlm.nih.gov/pubmed/29615693
http://dx.doi.org/10.1038/s41598-018-23801-9
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author Camargo, Milena
Soto-De León, Sara C.
Del Río-Ospina, Luisa
Páez, Astrid C.
González, Zanony
González, Edgardo
Cubides, Juan R.
Camargo-Ayala, Paola A.
Patarroyo, Manuel E.
Patarroyo, Manuel A.
author_facet Camargo, Milena
Soto-De León, Sara C.
Del Río-Ospina, Luisa
Páez, Astrid C.
González, Zanony
González, Edgardo
Cubides, Juan R.
Camargo-Ayala, Paola A.
Patarroyo, Manuel E.
Patarroyo, Manuel A.
author_sort Camargo, Milena
collection PubMed
description Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge about the population characteristics influencing the dispersal of parasite species is limited. This study aimed to determine the distribution patterns of Plasmodium vivax, P. malariae and P. falciparum single and mixed infections, as well as the significant socio-spatial groupings relating to the appearance of such infections. An active search in 57 localities resulted in 2,106 symptomatic patients being enrolled. Parasitaemia levels were assessed by optical microscopy, and parasites were detected by PCR. The association between mixed infections (in 43.2% of the population) and socio-spatial factors was modelled using logistic regression and multiple correspondence analyses. P. vivax occurred most frequently (71.0%), followed by P. malariae (43.2%), in all localities. The results suggest that a parasite density-dependent regulation model (with fever playing a central role) was appropriate for modelling the frequency of mixed species infections in this population. This study highlights the under-reporting of Plasmodium spp. mixed infections in the malaria-endemic area of the Colombian Amazon region and the association between causative and environmental factors in such areas.
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spelling pubmed-58830182018-04-09 Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region Camargo, Milena Soto-De León, Sara C. Del Río-Ospina, Luisa Páez, Astrid C. González, Zanony González, Edgardo Cubides, Juan R. Camargo-Ayala, Paola A. Patarroyo, Manuel E. Patarroyo, Manuel A. Sci Rep Article Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge about the population characteristics influencing the dispersal of parasite species is limited. This study aimed to determine the distribution patterns of Plasmodium vivax, P. malariae and P. falciparum single and mixed infections, as well as the significant socio-spatial groupings relating to the appearance of such infections. An active search in 57 localities resulted in 2,106 symptomatic patients being enrolled. Parasitaemia levels were assessed by optical microscopy, and parasites were detected by PCR. The association between mixed infections (in 43.2% of the population) and socio-spatial factors was modelled using logistic regression and multiple correspondence analyses. P. vivax occurred most frequently (71.0%), followed by P. malariae (43.2%), in all localities. The results suggest that a parasite density-dependent regulation model (with fever playing a central role) was appropriate for modelling the frequency of mixed species infections in this population. This study highlights the under-reporting of Plasmodium spp. mixed infections in the malaria-endemic area of the Colombian Amazon region and the association between causative and environmental factors in such areas. Nature Publishing Group UK 2018-04-03 /pmc/articles/PMC5883018/ /pubmed/29615693 http://dx.doi.org/10.1038/s41598-018-23801-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Camargo, Milena
Soto-De León, Sara C.
Del Río-Ospina, Luisa
Páez, Astrid C.
González, Zanony
González, Edgardo
Cubides, Juan R.
Camargo-Ayala, Paola A.
Patarroyo, Manuel E.
Patarroyo, Manuel A.
Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region
title Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region
title_full Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region
title_fullStr Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region
title_full_unstemmed Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region
title_short Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region
title_sort micro-epidemiology of mixed-species malaria infections in a rural population living in the colombian amazon region
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883018/
https://www.ncbi.nlm.nih.gov/pubmed/29615693
http://dx.doi.org/10.1038/s41598-018-23801-9
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