Cargando…

TAGLN2 polymerizes G-actin in a low ionic state but blocks Arp2/3-nucleated actin branching in physiological conditions

TAGLN is an actin-binding protein family that comprises three isoforms with theorized roles in smooth muscle differentiation, tumour development, lymphocyte activation, and brain chemistry. However, their fundamental characteristics in regulation of the actin-based cytoskeleton are not fully underst...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hye-Ran, Kwon, Min-Sung, Lee, Sangmin, Mun, YeVin, Lee, Kyung-Sik, Kim, Chang-Hyun, Na, Bo-Ra, Kim, Bit Na Rae, Piragyte, Indre, Lee, Hyun-Su, Jun, Youngsoo, Jin, Mi Sun, Hyun, Young-Min, Jung, Hyun Suk, Mun, Ji Young, Jun, Chang-Duk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883021/ https://www.ncbi.nlm.nih.gov/pubmed/29615809 http://dx.doi.org/10.1038/s41598-018-23816-2

Ejemplares similares

TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse
por: Na, Bo-Ra, et al.
Publicado: (2015)

Actin Engine in Immunological Synapse
por: Piragyte, Indre, et al.
Publicado: (2012)

TAGLN2-mediated actin stabilization at the immunological synapse: implication for cytotoxic T cell control of target cells
por: Na, Bo-Ra, et al.
Publicado: (2015)

An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages
por: Kim, Hye-Ran, et al.
Publicado: (2017)

Actin stabilizer TAGLN2 potentiates adoptive T cell therapy by boosting the inside-out costimulation via lymphocyte function-associated antigen-1
por: Jeon, Bu-Nam, et al.
Publicado: (2018)

Swiprosin-1 Is a Novel Actin Bundling Protein That Regulates Cell Spreading and Migration
por: Kwon, Min-Sung, et al.
Publicado: (2013)

Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves
por: Le Chua, Xiang, et al.
Publicado: (2023)

Tobacco Arp3 is localized to actin-nucleating sites in vivo
por: Maisch, Jan, et al.
Publicado: (2009)

Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments
por: LeClaire, Lawrence L., et al.
Publicado: (2008)

T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells
por: Kim, Hye-Ran, et al.
Publicado: (2018)

Swiprosin-1 modulates actin dynamics by regulating the F-actin accessibility to cofilin
por: Huh, Yun Hyun, et al.
Publicado: (2013)

Pivotal role of VASP in Arp2/3 complex–mediated actin nucleation, actin branch-formation, and Listeria monocytogenes motility
por: Skoble, Justin, et al.
Publicado: (2001)

Direct Visualization of Actin Filaments and Actin-Binding Proteins in Neuronal Cells
por: Jung, Minkyo, et al.
Publicado: (2020)

Methamphetamine-induced Occludin Endocytosis Is Mediated by the Arp2/3 Complex-regulated Actin Rearrangement
por: Park, Minseon, et al.
Publicado: (2013)

New nucleator for actin
por: LeBrasseur, Nicole
Publicado: (2007)

Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex
por: Rodnick-Smith, Max, et al.
Publicado: (2016)

Rac and Arp2/3-Nucleated Actin Networks Antagonize Rho During Mitotic and Meiotic Cleavages
por: Pal, Debadrita, et al.
Publicado: (2020)

Structural and Biochemical Characterization of EFhd1/Swiprosin-2, an Actin-Binding Protein in Mitochondria
por: Mun, Sang A., et al.
Publicado: (2021)

Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly
por: Liu, Su-Ling, et al.
Publicado: (2022)

The Saccharomyces cerevisiae actin-related protein Arp2 is involved in the actin cytoskeleton
Publicado: (1996)

Mechanism of Filament Nucleation and Branch Stability Revealed by the Structure of the Arp2/3 Complex at Actin Branch Junctions
por: Egile, Coumaran, et al.
Publicado: (2005)

Elucidating Key Motifs Required for Arp2/3-Dependent and Independent Actin Nucleation by Las17/WASP
por: Allwood, Ellen G., et al.
Publicado: (2016)

Structural Analysis of Human Fascin-1: Essential Protein for Actin Filaments Bundling
por: Chung, Jeong Min, et al.
Publicado: (2022)

Activation of the Cdc42 Effector N-Wasp by the Shigella flexneri Icsa Protein Promotes Actin Nucleation by Arp2/3 Complex and Bacterial Actin-Based Motility
por: Egile, Coumaran, et al.
Publicado: (1999)

Three Regions within Acta Promote Arp2/3 Complex-Mediated Actin Nucleation and Listeria monocytogenes Motility
por: Skoble, Justin, et al.
Publicado: (2000)

An Order of Magnitude Faster AIP1-Associated Actin Disruption than Nucleation by the Arp2/3 Complex in Lamellipodia
por: Tsuji, Takahiro, et al.
Publicado: (2009)

A WAVE2–Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens
por: Verma, Suzie, et al.
Publicado: (2012)

Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF
por: Guo, Siyang, et al.
Publicado: (2018)

Evolutionary diversification reveals distinct somatic versus germline cytoskeletal functions of the Arp2 branched actin nucleator protein
por: Stromberg, Kaitlin A., et al.
Publicado: (2023)

Turning the Actin Nucleating Compound Miuraenamide into Nucleation Inhibitors
por: Wang, Shuaijun, et al.
Publicado: (2021)

Integration of linear and dendritic actin nucleation in Nck-induced actin comets
por: Borinskaya, Sofya, et al.
Publicado: (2016)

Treatment of Actinic Keratosis: The Best Choice through an Observational Study
por: Yoo, Seung-Ah, et al.
Publicado: (2022)

Photodynamic Therapy with Ablative Carbon Dioxide Fractional Laser in Treatment of Actinic Keratosis
por: Jang, Yong Hyun, et al.
Publicado: (2013)

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms
por: von Loeffelholz, Ottilie, et al.
Publicado: (2020)

The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis
por: King, Virginia L., et al.
Publicado: (2021)

Branching out in different directions: Emerging cellular functions for the Arp2/3 complex and WASP-family actin nucleation factors
por: Campellone, Kenneth G., et al.
Publicado: (2023)

Molecular dynamics simulations support a multistep pathway for activation of branched actin filament nucleation by Arp2/3 complex
por: Singh, Yuvraj, et al.
Publicado: (2023)

Cellular Control of Cortical Actin Nucleation
por: Bovellan, Miia, et al.
Publicado: (2014)

Three’s not a crowd for actin nucleators
por: Leslie, Mitch
Publicado: (2013)

Regulation of actin nucleation and autophagosome formation
por: Coutts, Amanda S., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hktj31amr5su45gvdsnj8ednfq