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Rescue of conformational dynamics in enzyme catalysis by directed evolution

Rational design and directed evolution have proved to be successful approaches to increase catalytic efficiencies of both natural and artificial enzymes. Protein dynamics is recognized as important, but due to the inherent flexibility of biological macromolecules it is often difficult to distinguish...

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Detalles Bibliográficos
Autores principales:	Otten, Renee, Liu, Lin, Kenner, Lillian R., Clarkson, Michael W., Mavor, David, Tawfik, Dan S., Kern, Dorothee, Fraser, James S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883053/ https://www.ncbi.nlm.nih.gov/pubmed/29615624 http://dx.doi.org/10.1038/s41467-018-03562-9

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