Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper understanding of the consequences of this oncogenic mutation. One aspect of the neomorphic function of the IDH1 R132H enzyme that has received less a...

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Detalles Bibliográficos
Autores principales: Hollinshead, Kate E.R., Munford, Haydn, Eales, Katherine L., Bardella, Chiara, Li, Chunjie, Escribano-Gonzalez, Cristina, Thakker, Alpesh, Nonnenmacher, Yannic, Kluckova, Katarina, Jeeves, Mark, Murren, Robert, Cuozzo, Federica, Ye, Dan, Laurenti, Giulio, Zhu, Wei, Hiller, Karsten, Hodson, David J., Hua, Wei, Tomlinson, Ian P., Ludwig, Christian, Mao, Ying, Tennant, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883319/
https://www.ncbi.nlm.nih.gov/pubmed/29562167
http://dx.doi.org/10.1016/j.celrep.2018.02.084

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