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Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain

BACKGROUND: Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid (Aβ) peptides and hyperphosphorylated tau protein accompanied by neuronal loss. Aβ accumulation has been associated with an impaired sphingosine 1-phosphate (S1P) metabolism. S1P is generated by sphingosine kinase...

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Detalles Bibliográficos
Autores principales:	Dominguez, Gaëlle, Maddelein, Marie-Lise, Pucelle, Mélanie, Nicaise, Yvan, Maurage, Claude-Alain, Duyckaerts, Charles, Cuvillier, Olivier, Delisle, Marie-Bernadette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883421/ https://www.ncbi.nlm.nih.gov/pubmed/29615132 http://dx.doi.org/10.1186/s40478-018-0527-z

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