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A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015
In May 2015, following a 30-year diphtheria-free interval in Catalonia, an unvaccinated 6-year-old child was diagnosed with diphtheria caused by toxigenic Corynebacterium diphtheriae. After a difficult search for equine-derived diphtheria antitoxin (DAT), the child received the DAT 4 days later but...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883453/ https://www.ncbi.nlm.nih.gov/pubmed/29616610 http://dx.doi.org/10.2807/1560-7917.ES.2018.23.13.17-00183 |
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author | Jané, Mireia Vidal, Maria José Camps, Neus Campins, Magda Martínez, Ana Balcells, Joan Martin-Gomez, Maria Teresa Bassets, Gloria Herrera-León, Silvia Foguet, Anton Maresma, Mar Follia, Nuria Uriona, Sonia Pumarola, Tomàs |
author_facet | Jané, Mireia Vidal, Maria José Camps, Neus Campins, Magda Martínez, Ana Balcells, Joan Martin-Gomez, Maria Teresa Bassets, Gloria Herrera-León, Silvia Foguet, Anton Maresma, Mar Follia, Nuria Uriona, Sonia Pumarola, Tomàs |
author_sort | Jané, Mireia |
collection | PubMed |
description | In May 2015, following a 30-year diphtheria-free interval in Catalonia, an unvaccinated 6-year-old child was diagnosed with diphtheria caused by toxigenic Corynebacterium diphtheriae. After a difficult search for equine-derived diphtheria antitoxin (DAT), the child received the DAT 4 days later but died at the end of June. Two hundred and seventeen contacts were identified in relation to the index case, and their vaccination statuses were analysed, updated and completed. Of these, 140 contacts underwent physical examination and throat swabs were taken from them for analysis. Results were positive for toxigenic C. diphtheriae in 10 contacts; nine were asymptomatic vaccinated children who had been in contact with the index case and one was a parent of one of the nine children. Active surveillance of the 217 contacts was initiated by healthcare workers from hospitals and primary healthcare centres, together with public health epidemiological support. Lack of availability of DAT was an issue in our case. Such lack could be circumvented by the implementation of an international fast-track procedure to obtain it in a timely manner. Maintaining primary vaccination coverage for children and increasing booster-dose immunisation against diphtheria in the adult population is of key importance. |
format | Online Article Text |
id | pubmed-5883453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-58834532018-04-13 A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015 Jané, Mireia Vidal, Maria José Camps, Neus Campins, Magda Martínez, Ana Balcells, Joan Martin-Gomez, Maria Teresa Bassets, Gloria Herrera-León, Silvia Foguet, Anton Maresma, Mar Follia, Nuria Uriona, Sonia Pumarola, Tomàs Euro Surveill Surveillance and Outbreak Report In May 2015, following a 30-year diphtheria-free interval in Catalonia, an unvaccinated 6-year-old child was diagnosed with diphtheria caused by toxigenic Corynebacterium diphtheriae. After a difficult search for equine-derived diphtheria antitoxin (DAT), the child received the DAT 4 days later but died at the end of June. Two hundred and seventeen contacts were identified in relation to the index case, and their vaccination statuses were analysed, updated and completed. Of these, 140 contacts underwent physical examination and throat swabs were taken from them for analysis. Results were positive for toxigenic C. diphtheriae in 10 contacts; nine were asymptomatic vaccinated children who had been in contact with the index case and one was a parent of one of the nine children. Active surveillance of the 217 contacts was initiated by healthcare workers from hospitals and primary healthcare centres, together with public health epidemiological support. Lack of availability of DAT was an issue in our case. Such lack could be circumvented by the implementation of an international fast-track procedure to obtain it in a timely manner. Maintaining primary vaccination coverage for children and increasing booster-dose immunisation against diphtheria in the adult population is of key importance. European Centre for Disease Prevention and Control (ECDC) 2018-03-29 /pmc/articles/PMC5883453/ /pubmed/29616610 http://dx.doi.org/10.2807/1560-7917.ES.2018.23.13.17-00183 Text en This article is copyright of The Authors, 2018. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Surveillance and Outbreak Report Jané, Mireia Vidal, Maria José Camps, Neus Campins, Magda Martínez, Ana Balcells, Joan Martin-Gomez, Maria Teresa Bassets, Gloria Herrera-León, Silvia Foguet, Anton Maresma, Mar Follia, Nuria Uriona, Sonia Pumarola, Tomàs A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015 |
title | A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015 |
title_full | A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015 |
title_fullStr | A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015 |
title_full_unstemmed | A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015 |
title_short | A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015 |
title_sort | case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, catalonia, spain, 2015 |
topic | Surveillance and Outbreak Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883453/ https://www.ncbi.nlm.nih.gov/pubmed/29616610 http://dx.doi.org/10.2807/1560-7917.ES.2018.23.13.17-00183 |
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