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A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015

In May 2015, following a 30-year diphtheria-free interval in Catalonia, an unvaccinated 6-year-old child was diagnosed with diphtheria caused by toxigenic Corynebacterium diphtheriae. After a difficult search for equine-derived diphtheria antitoxin (DAT), the child received the DAT 4 days later but...

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Autores principales: Jané, Mireia, Vidal, Maria José, Camps, Neus, Campins, Magda, Martínez, Ana, Balcells, Joan, Martin-Gomez, Maria Teresa, Bassets, Gloria, Herrera-León, Silvia, Foguet, Anton, Maresma, Mar, Follia, Nuria, Uriona, Sonia, Pumarola, Tomàs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883453/
https://www.ncbi.nlm.nih.gov/pubmed/29616610
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.13.17-00183
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author Jané, Mireia
Vidal, Maria José
Camps, Neus
Campins, Magda
Martínez, Ana
Balcells, Joan
Martin-Gomez, Maria Teresa
Bassets, Gloria
Herrera-León, Silvia
Foguet, Anton
Maresma, Mar
Follia, Nuria
Uriona, Sonia
Pumarola, Tomàs
author_facet Jané, Mireia
Vidal, Maria José
Camps, Neus
Campins, Magda
Martínez, Ana
Balcells, Joan
Martin-Gomez, Maria Teresa
Bassets, Gloria
Herrera-León, Silvia
Foguet, Anton
Maresma, Mar
Follia, Nuria
Uriona, Sonia
Pumarola, Tomàs
author_sort Jané, Mireia
collection PubMed
description In May 2015, following a 30-year diphtheria-free interval in Catalonia, an unvaccinated 6-year-old child was diagnosed with diphtheria caused by toxigenic Corynebacterium diphtheriae. After a difficult search for equine-derived diphtheria antitoxin (DAT), the child received the DAT 4 days later but died at the end of June. Two hundred and seventeen contacts were identified in relation to the index case, and their vaccination statuses were analysed, updated and completed. Of these, 140 contacts underwent physical examination and throat swabs were taken from them for analysis. Results were positive for toxigenic C. diphtheriae in 10 contacts; nine were asymptomatic vaccinated children who had been in contact with the index case and one was a parent of one of the nine children. Active surveillance of the 217 contacts was initiated by healthcare workers from hospitals and primary healthcare centres, together with public health epidemiological support. Lack of availability of DAT was an issue in our case. Such lack could be circumvented by the implementation of an international fast-track procedure to obtain it in a timely manner. Maintaining primary vaccination coverage for children and increasing booster-dose immunisation against diphtheria in the adult population is of key importance.
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spelling pubmed-58834532018-04-13 A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015 Jané, Mireia Vidal, Maria José Camps, Neus Campins, Magda Martínez, Ana Balcells, Joan Martin-Gomez, Maria Teresa Bassets, Gloria Herrera-León, Silvia Foguet, Anton Maresma, Mar Follia, Nuria Uriona, Sonia Pumarola, Tomàs Euro Surveill Surveillance and Outbreak Report In May 2015, following a 30-year diphtheria-free interval in Catalonia, an unvaccinated 6-year-old child was diagnosed with diphtheria caused by toxigenic Corynebacterium diphtheriae. After a difficult search for equine-derived diphtheria antitoxin (DAT), the child received the DAT 4 days later but died at the end of June. Two hundred and seventeen contacts were identified in relation to the index case, and their vaccination statuses were analysed, updated and completed. Of these, 140 contacts underwent physical examination and throat swabs were taken from them for analysis. Results were positive for toxigenic C. diphtheriae in 10 contacts; nine were asymptomatic vaccinated children who had been in contact with the index case and one was a parent of one of the nine children. Active surveillance of the 217 contacts was initiated by healthcare workers from hospitals and primary healthcare centres, together with public health epidemiological support. Lack of availability of DAT was an issue in our case. Such lack could be circumvented by the implementation of an international fast-track procedure to obtain it in a timely manner. Maintaining primary vaccination coverage for children and increasing booster-dose immunisation against diphtheria in the adult population is of key importance. European Centre for Disease Prevention and Control (ECDC) 2018-03-29 /pmc/articles/PMC5883453/ /pubmed/29616610 http://dx.doi.org/10.2807/1560-7917.ES.2018.23.13.17-00183 Text en This article is copyright of The Authors, 2018. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Jané, Mireia
Vidal, Maria José
Camps, Neus
Campins, Magda
Martínez, Ana
Balcells, Joan
Martin-Gomez, Maria Teresa
Bassets, Gloria
Herrera-León, Silvia
Foguet, Anton
Maresma, Mar
Follia, Nuria
Uriona, Sonia
Pumarola, Tomàs
A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015
title A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015
title_full A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015
title_fullStr A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015
title_full_unstemmed A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015
title_short A case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, Catalonia, Spain, 2015
title_sort case of respiratory toxigenic diphtheria: contact tracing results and considerations following a 30-year disease-free interval, catalonia, spain, 2015
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883453/
https://www.ncbi.nlm.nih.gov/pubmed/29616610
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.13.17-00183
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