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Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanoma

BACKGROUND: Kinase inhibition in the mitogen activated protein kinase (MAPK) pathway is a standard therapy for cancer patients with activating BRAF mutations. However, the anti-tumorigenic effect and clinical benefit are only transient, and tumors are prone to treatment resistance and relapse. To el...

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Detalles Bibliográficos
Autores principales:	Zecena, Helma, Tveit, Daniel, Wang, Zi, Farhat, Ahmed, Panchal, Parvita, Liu, Jing, Singh, Simar J., Sanghera, Amandeep, Bainiwal, Ajay, Teo, Shuan Y., Meyskens, Frank L., Liu-Smith, Feng, Filipp, Fabian V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883534/ https://www.ncbi.nlm.nih.gov/pubmed/29615030 http://dx.doi.org/10.1186/s12918-018-0554-1

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