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Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese

OBJECTIVES: Both acid-sensing ion channel acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) have been proposed to be involved in the pathophysiology of hypertension. Common colocalization of ASIC3 and TRPV1 channels in the same sensory neuron has been reported....

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Autores principales: Er, Leay-Kiaw, Teng, Ming-Sheng, Wu, Semon, Hsu, Lung-An, Tzeng, I-Shiang, Cheng, Ching-Feng, Chang, Hsin-I, Chou, Hsin-Hua, Ko, Yu-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883834/
https://www.ncbi.nlm.nih.gov/pubmed/29643714
http://dx.doi.org/10.4103/tcmj.tcmj_187_17
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author Er, Leay-Kiaw
Teng, Ming-Sheng
Wu, Semon
Hsu, Lung-An
Tzeng, I-Shiang
Cheng, Ching-Feng
Chang, Hsin-I
Chou, Hsin-Hua
Ko, Yu-Lin
author_facet Er, Leay-Kiaw
Teng, Ming-Sheng
Wu, Semon
Hsu, Lung-An
Tzeng, I-Shiang
Cheng, Ching-Feng
Chang, Hsin-I
Chou, Hsin-Hua
Ko, Yu-Lin
author_sort Er, Leay-Kiaw
collection PubMed
description OBJECTIVES: Both acid-sensing ion channel acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) have been proposed to be involved in the pathophysiology of hypertension. Common colocalization of ASIC3 and TRPV1 channels in the same sensory neuron has been reported. We aimed to study the combined ASIC3 and TRPV1 gene polymorphisms in the risk of hypertension. MATERIALS AND METHODS: To test the statistical association between genetic polymorphisms of the ASIC3 and TRPV1 genes and blood pressure (BP) variations in Taiwanese, 551 unrelated individuals (286 men and 265 women) having routine health examinations were recruited. The participants had no history of cardiovascular disease or use of medication for hypertension. RESULTS: Six ASIC3 and four TRPV1 gene polymorphisms were genotyped, and only the ASIC3 rs2288646 polymorphism was associated with variations in BP in the participants. In subgroup analysis, we found participants carrying the combined ASIC3 rs2288646 AA or AG and TRPV1 rs8065080 CC genotypes (combined genotypes) had significantly higher systolic, mean and diastolic BP compared with the other subgroups (P = 0.009, 0.003, and 0.006, respectively, after Bonferroni correction). Interaction analysis also revealed significant gene-gene interaction in the systolic, mean, and diastolic BP in the ASIC3 and TRPV1 genotypes (interaction P = 0.006, 0.002, and 0.002, respectively). A trend of increasing frequencies of the combined genotype was observed in normotensive, prehypertensive, and hypertensive subgroups (P for trend = 0.001), as well as in those with higher systolic and diastolic BPs (P for trend = 9.13 × 10(−4) and P for trend = 5.5 × 10(−5), respectively). CONCLUSION: Our data show a combined effect of ASIC3 and TRPV1 gene polymorphisms in BP variations in Taiwanese. These results suggest that the interaction between ASIC3 and TRPV1 is involved in BP regulation.
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spelling pubmed-58838342018-04-11 Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese Er, Leay-Kiaw Teng, Ming-Sheng Wu, Semon Hsu, Lung-An Tzeng, I-Shiang Cheng, Ching-Feng Chang, Hsin-I Chou, Hsin-Hua Ko, Yu-Lin Tzu Chi Med J Original Article OBJECTIVES: Both acid-sensing ion channel acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) have been proposed to be involved in the pathophysiology of hypertension. Common colocalization of ASIC3 and TRPV1 channels in the same sensory neuron has been reported. We aimed to study the combined ASIC3 and TRPV1 gene polymorphisms in the risk of hypertension. MATERIALS AND METHODS: To test the statistical association between genetic polymorphisms of the ASIC3 and TRPV1 genes and blood pressure (BP) variations in Taiwanese, 551 unrelated individuals (286 men and 265 women) having routine health examinations were recruited. The participants had no history of cardiovascular disease or use of medication for hypertension. RESULTS: Six ASIC3 and four TRPV1 gene polymorphisms were genotyped, and only the ASIC3 rs2288646 polymorphism was associated with variations in BP in the participants. In subgroup analysis, we found participants carrying the combined ASIC3 rs2288646 AA or AG and TRPV1 rs8065080 CC genotypes (combined genotypes) had significantly higher systolic, mean and diastolic BP compared with the other subgroups (P = 0.009, 0.003, and 0.006, respectively, after Bonferroni correction). Interaction analysis also revealed significant gene-gene interaction in the systolic, mean, and diastolic BP in the ASIC3 and TRPV1 genotypes (interaction P = 0.006, 0.002, and 0.002, respectively). A trend of increasing frequencies of the combined genotype was observed in normotensive, prehypertensive, and hypertensive subgroups (P for trend = 0.001), as well as in those with higher systolic and diastolic BPs (P for trend = 9.13 × 10(−4) and P for trend = 5.5 × 10(−5), respectively). CONCLUSION: Our data show a combined effect of ASIC3 and TRPV1 gene polymorphisms in BP variations in Taiwanese. These results suggest that the interaction between ASIC3 and TRPV1 is involved in BP regulation. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5883834/ /pubmed/29643714 http://dx.doi.org/10.4103/tcmj.tcmj_187_17 Text en Copyright: © 2018 Tzu Chi Medical Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Er, Leay-Kiaw
Teng, Ming-Sheng
Wu, Semon
Hsu, Lung-An
Tzeng, I-Shiang
Cheng, Ching-Feng
Chang, Hsin-I
Chou, Hsin-Hua
Ko, Yu-Lin
Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese
title Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese
title_full Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese
title_fullStr Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese
title_full_unstemmed Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese
title_short Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese
title_sort combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in taiwanese
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883834/
https://www.ncbi.nlm.nih.gov/pubmed/29643714
http://dx.doi.org/10.4103/tcmj.tcmj_187_17
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