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Research of a novel biodegradable surgical staple made of high purity magnesium
Surgical staples made of pure titanium and titanium alloys are widely used in gastrointestinal anastomosis. However the Ti staple cannot be absorbed in human body and produce artifacts on computed tomography (CT) and other imaging examination, and cause the risk of incorrect diagnosis. The bioabsorb...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883960/ https://www.ncbi.nlm.nih.gov/pubmed/29744400 http://dx.doi.org/10.1016/j.bioactmat.2016.09.005 |
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author | Wu, Hongliu Zhao, Changli Ni, Jiahua Zhang, Shaoxiang Liu, Jingyi Yan, Jun Chen, Yigang Zhang, Xiaonong |
author_facet | Wu, Hongliu Zhao, Changli Ni, Jiahua Zhang, Shaoxiang Liu, Jingyi Yan, Jun Chen, Yigang Zhang, Xiaonong |
author_sort | Wu, Hongliu |
collection | PubMed |
description | Surgical staples made of pure titanium and titanium alloys are widely used in gastrointestinal anastomosis. However the Ti staple cannot be absorbed in human body and produce artifacts on computed tomography (CT) and other imaging examination, and cause the risk of incorrect diagnosis. The bioabsorbable staple made from polymers that can degrade in human body environment, is an alternative. In the present study, biodegradable high purity magnesium staples were developed for gastric anastomosis. U-shape staples with two different interior angles, namely original 90° and modified 100°, were designed. Finite element analysis (FEA) showed that the residual stress concentrated on the arc part when the original staple was closed to B-shape, while it concentrated on the feet for the modified staple after closure. The in vitro tests indicated that the arc part of the original staple ruptured firstly after 7 days immersion, whereas the modified one kept intact, demonstrating residual stress greatly affected the corrosion behavior of the HP-Mg staples. The in vivo implantation showed good biocompatibility of the modified Mg staples, without inflammatory reaction 9 weeks post-operation. The Mg staples kept good closure to the Anastomosis, no leaking and bleeding were found, and the staples exhibited no fracture or severe corrosion cracks during the degradation. |
format | Online Article Text |
id | pubmed-5883960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-58839602018-05-09 Research of a novel biodegradable surgical staple made of high purity magnesium Wu, Hongliu Zhao, Changli Ni, Jiahua Zhang, Shaoxiang Liu, Jingyi Yan, Jun Chen, Yigang Zhang, Xiaonong Bioact Mater Bioactive metals and alloy Surgical staples made of pure titanium and titanium alloys are widely used in gastrointestinal anastomosis. However the Ti staple cannot be absorbed in human body and produce artifacts on computed tomography (CT) and other imaging examination, and cause the risk of incorrect diagnosis. The bioabsorbable staple made from polymers that can degrade in human body environment, is an alternative. In the present study, biodegradable high purity magnesium staples were developed for gastric anastomosis. U-shape staples with two different interior angles, namely original 90° and modified 100°, were designed. Finite element analysis (FEA) showed that the residual stress concentrated on the arc part when the original staple was closed to B-shape, while it concentrated on the feet for the modified staple after closure. The in vitro tests indicated that the arc part of the original staple ruptured firstly after 7 days immersion, whereas the modified one kept intact, demonstrating residual stress greatly affected the corrosion behavior of the HP-Mg staples. The in vivo implantation showed good biocompatibility of the modified Mg staples, without inflammatory reaction 9 weeks post-operation. The Mg staples kept good closure to the Anastomosis, no leaking and bleeding were found, and the staples exhibited no fracture or severe corrosion cracks during the degradation. KeAi Publishing 2016-10-05 /pmc/articles/PMC5883960/ /pubmed/29744400 http://dx.doi.org/10.1016/j.bioactmat.2016.09.005 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Bioactive metals and alloy Wu, Hongliu Zhao, Changli Ni, Jiahua Zhang, Shaoxiang Liu, Jingyi Yan, Jun Chen, Yigang Zhang, Xiaonong Research of a novel biodegradable surgical staple made of high purity magnesium |
title | Research of a novel biodegradable surgical staple made of high purity magnesium |
title_full | Research of a novel biodegradable surgical staple made of high purity magnesium |
title_fullStr | Research of a novel biodegradable surgical staple made of high purity magnesium |
title_full_unstemmed | Research of a novel biodegradable surgical staple made of high purity magnesium |
title_short | Research of a novel biodegradable surgical staple made of high purity magnesium |
title_sort | research of a novel biodegradable surgical staple made of high purity magnesium |
topic | Bioactive metals and alloy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883960/ https://www.ncbi.nlm.nih.gov/pubmed/29744400 http://dx.doi.org/10.1016/j.bioactmat.2016.09.005 |
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