A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer

Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti–colorectal cancer (CRC) activity of SL-1, a DNA-directed N-mustard-quinoline conjugate. The N-mustard moiety in SL-1 induced DNA strand breaks, interstrand cross-links (ICLs)...

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Detalles Bibliográficos
Autores principales: Chen, Tai-Lin, Lin, Yi-Wen, Chen, Yan-Bo, Lin, Jing-Jer, Su, Tsann-Long, Shen, Chia-Ning, Lee, Te-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884014/
https://www.ncbi.nlm.nih.gov/pubmed/29247884
http://dx.doi.org/10.1016/j.neo.2017.11.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884014/
https://www.ncbi.nlm.nih.gov/pubmed/29247884
http://dx.doi.org/10.1016/j.neo.2017.11.006

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