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Changes in Sensitivity to the Effects of Atrazine on the Luteinizing Hormone Surge in Female Sprague-Dawley Rats after Repeated Daily Doses: Correlation with Liver Enzyme Expression
BACKGROUND: Atrazine suppression of the LH surge slowly develops over time and peaks after 4 days; sensitivity to atrazine decreases after 8 or 14 days of dosing. Adaptation of the LH response was correlated with increased phase I and phase II liver enzyme activity/expression. METHODS: The effect of...
Autores principales: | Breckenridge, Charles B., Foradori, Chad D., Coder, Pragati Sawhney, Simpkins, James W., Sielken, Robert L., Handa, Robert J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884089/ https://www.ncbi.nlm.nih.gov/pubmed/29134775 http://dx.doi.org/10.1002/bdr2.1130 |
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