Imaging intralesional heterogeneity of sodium concentration in multiple sclerosis: Initial evidence from (23)Na-MRI

Sodium MRI ((23)Na-MRI) has been used to non-invasively quantify tissue sodium but has been limited by low spatial resolution. Here we demonstrate for the first time that high resolution (23)Na-MRI reveals the spatial heterogeneity of sodium concentration within a multiple sclerosis (MS) lesion. A p...

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Detalles Bibliográficos
Autores principales: Grist, James T., Riemer, Frank, McLean, Mary A., Matys, Tomasz, Zaccagna, Fulvio, Hilborne, Sarah F., Mason, Jackie P., Patterson, Ilse, Slough, Rhys, Kaggie, Joshua, Deen, Surrin S., Graves, Martin J., Jones, Joanne L., Coles, Alasdair J., Gallagher, Ferdia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884312/
https://www.ncbi.nlm.nih.gov/pubmed/29571845
http://dx.doi.org/10.1016/j.jns.2018.01.027
Descripción
Sumario:Sodium MRI ((23)Na-MRI) has been used to non-invasively quantify tissue sodium but has been limited by low spatial resolution. Here we demonstrate for the first time that high resolution (23)Na-MRI reveals the spatial heterogeneity of sodium concentration within a multiple sclerosis (MS) lesion. A patient with treatment-naïve relapsing-remitting MS and a ring-enhancing lesion was imaged using (23)Na-MRI. The periphery of the lesion demonstrated an elevated total sodium content compared to the normal appearing white and grey matter (p < 0.01), as well as a heterogeneous distribution of both the total tissue sodium concentration and the intracellular-weighted sodium concentration.

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