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Spontaneous Regression of Metastatic Papillary Thyroid Cancer in a Lymph Node

Spontaneous regression of cancer is defined as disappearance of cancer in the absence of specific therapy. In thyroid cancer patients with biochemically incomplete response to initial treatments, spontaneous decline in thyroglobulin levels without any cancer treatment is a well-known phenomenon; how...

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Detalles Bibliográficos
Autores principales: Shim, Jien, Rao, Jianyu, Yu, Run
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884408/
https://www.ncbi.nlm.nih.gov/pubmed/29755799
http://dx.doi.org/10.1155/2018/5873897
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author Shim, Jien
Rao, Jianyu
Yu, Run
author_facet Shim, Jien
Rao, Jianyu
Yu, Run
author_sort Shim, Jien
collection PubMed
description Spontaneous regression of cancer is defined as disappearance of cancer in the absence of specific therapy. In thyroid cancer patients with biochemically incomplete response to initial treatments, spontaneous decline in thyroglobulin levels without any cancer treatment is a well-known phenomenon; however, spontaneous regression of persistent or recurrent structural disease has not been reported. We here present a case of papillary thyroid cancer in a 58-year-old female who underwent total thyroidectomy and two radioiodine ablations. She had persistently elevated thyroglobulin levels. Six years after her initial treatments, she had biopsy-proven cervical lymph node metastasis. The patient opted not to undergo any further treatment. Over the course of the next 10 years, without any additional treatment, the lymph node disappeared and her thyroglobulin levels decreased to almost undetectable ranges, implying near-complete regression. Our case illustrates that metastatic papillary thyroid cancer in lymph nodes can regress spontaneously.
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spelling pubmed-58844082018-05-13 Spontaneous Regression of Metastatic Papillary Thyroid Cancer in a Lymph Node Shim, Jien Rao, Jianyu Yu, Run Case Rep Endocrinol Case Report Spontaneous regression of cancer is defined as disappearance of cancer in the absence of specific therapy. In thyroid cancer patients with biochemically incomplete response to initial treatments, spontaneous decline in thyroglobulin levels without any cancer treatment is a well-known phenomenon; however, spontaneous regression of persistent or recurrent structural disease has not been reported. We here present a case of papillary thyroid cancer in a 58-year-old female who underwent total thyroidectomy and two radioiodine ablations. She had persistently elevated thyroglobulin levels. Six years after her initial treatments, she had biopsy-proven cervical lymph node metastasis. The patient opted not to undergo any further treatment. Over the course of the next 10 years, without any additional treatment, the lymph node disappeared and her thyroglobulin levels decreased to almost undetectable ranges, implying near-complete regression. Our case illustrates that metastatic papillary thyroid cancer in lymph nodes can regress spontaneously. Hindawi 2018-03-20 /pmc/articles/PMC5884408/ /pubmed/29755799 http://dx.doi.org/10.1155/2018/5873897 Text en Copyright © 2018 Jien Shim et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shim, Jien
Rao, Jianyu
Yu, Run
Spontaneous Regression of Metastatic Papillary Thyroid Cancer in a Lymph Node
title Spontaneous Regression of Metastatic Papillary Thyroid Cancer in a Lymph Node
title_full Spontaneous Regression of Metastatic Papillary Thyroid Cancer in a Lymph Node
title_fullStr Spontaneous Regression of Metastatic Papillary Thyroid Cancer in a Lymph Node
title_full_unstemmed Spontaneous Regression of Metastatic Papillary Thyroid Cancer in a Lymph Node
title_short Spontaneous Regression of Metastatic Papillary Thyroid Cancer in a Lymph Node
title_sort spontaneous regression of metastatic papillary thyroid cancer in a lymph node
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884408/
https://www.ncbi.nlm.nih.gov/pubmed/29755799
http://dx.doi.org/10.1155/2018/5873897
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