Radically truncated MeCP2 rescues Rett syndrome-like neurological defects

Heterozygous mutations in the X-linked MECP2 gene cause the profound neurological disorder Rett syndrome (RTT)1. MeCP2 protein is an epigenetic reader whose binding to chromatin primarily depends on 5-methylcytosine (mC)2,3. Functionally, MeCP2 has been implicated in several cellular processes based...

Descripción completa

Detalles Bibliográficos
Autores principales: Tillotson, Rebekah, Selfridge, Jim, Koerner, Martha V., Gadalla, Kamal K. E., Guy, Jacky, De Sousa, Dina, Hector, Ralph D., Cobb, Stuart R., Bird, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884422/
https://www.ncbi.nlm.nih.gov/pubmed/29019980
http://dx.doi.org/10.1038/nature24058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884422/
https://www.ncbi.nlm.nih.gov/pubmed/29019980
http://dx.doi.org/10.1038/nature24058

Ejemplares similares