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Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems

BACKGROUND AND AIM: There are several prognostic systems that address different aspects of the patient and the tumour and can guide the management of patients with hepatocellular carcinoma (HCC). This study aimed to evaluate and compare the eight staging systems for a group of patients in a public s...

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Autores principales: Tannus, R. K., Almeida-Carvalho, S. R., Loureiro-Matos, C. A., Miziara-Gonzalez, A., Salzedas-Netto, A. A., Szejnfeld, D., D'Ippolito, G., Pereira-Lanzoni, V., Souza-Silva, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884519/
https://www.ncbi.nlm.nih.gov/pubmed/29617435
http://dx.doi.org/10.1371/journal.pone.0194922
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author Tannus, R. K.
Almeida-Carvalho, S. R.
Loureiro-Matos, C. A.
Miziara-Gonzalez, A.
Salzedas-Netto, A. A.
Szejnfeld, D.
D'Ippolito, G.
Pereira-Lanzoni, V.
Souza-Silva, I.
author_facet Tannus, R. K.
Almeida-Carvalho, S. R.
Loureiro-Matos, C. A.
Miziara-Gonzalez, A.
Salzedas-Netto, A. A.
Szejnfeld, D.
D'Ippolito, G.
Pereira-Lanzoni, V.
Souza-Silva, I.
author_sort Tannus, R. K.
collection PubMed
description BACKGROUND AND AIM: There are several prognostic systems that address different aspects of the patient and the tumour and can guide the management of patients with hepatocellular carcinoma (HCC). This study aimed to evaluate and compare the eight staging systems for a group of patients in a public service in Brazil. METHODS: Patients with HCC were retrospectively analysed between 2000 and 2012. The prognostic systems Okuda, The Cancer of the Liver Italian Program (CLIP), the Chinese University Prognostic Index (CUPI), Groupe d'Etude et de Traitément du Carcinome Hepatocellulaire (GRETCH), the modified TNM-based Japan Integrated Score (JIS) combined with alpha-fetoprotein and Child-Turcotte-Pugh (CTP), the TNM system, and the Barcelona Clinic Liver Cancer Classification (BCLC) were applied to these patients and compared through model fit measurements, likelihood scores, and the Akaike Information Criterion (AIC). RESULTS: A total of 247 patients were studied. The average survival time was 60 months. The TNM, Okuda, CLIP, GRETCH, modified JIS, and BCLC systems were well correlated with one another and individually important to the prediction of survival among the patients studied. However, in the statistical analysis, the CUPI delivered the best predictive performance (AIC = 566; log-likelihood = -281,240). CONCLUSION: Although the CUPI system was demonstrated to be the most appropriate HCC staging system for the studied population, the choice of an ideal system is a controversial subject, and future studies with larger numbers of patients are necessary for the validation of the CUPI system as the method of choice for other populations.
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spelling pubmed-58845192018-04-13 Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems Tannus, R. K. Almeida-Carvalho, S. R. Loureiro-Matos, C. A. Miziara-Gonzalez, A. Salzedas-Netto, A. A. Szejnfeld, D. D'Ippolito, G. Pereira-Lanzoni, V. Souza-Silva, I. PLoS One Research Article BACKGROUND AND AIM: There are several prognostic systems that address different aspects of the patient and the tumour and can guide the management of patients with hepatocellular carcinoma (HCC). This study aimed to evaluate and compare the eight staging systems for a group of patients in a public service in Brazil. METHODS: Patients with HCC were retrospectively analysed between 2000 and 2012. The prognostic systems Okuda, The Cancer of the Liver Italian Program (CLIP), the Chinese University Prognostic Index (CUPI), Groupe d'Etude et de Traitément du Carcinome Hepatocellulaire (GRETCH), the modified TNM-based Japan Integrated Score (JIS) combined with alpha-fetoprotein and Child-Turcotte-Pugh (CTP), the TNM system, and the Barcelona Clinic Liver Cancer Classification (BCLC) were applied to these patients and compared through model fit measurements, likelihood scores, and the Akaike Information Criterion (AIC). RESULTS: A total of 247 patients were studied. The average survival time was 60 months. The TNM, Okuda, CLIP, GRETCH, modified JIS, and BCLC systems were well correlated with one another and individually important to the prediction of survival among the patients studied. However, in the statistical analysis, the CUPI delivered the best predictive performance (AIC = 566; log-likelihood = -281,240). CONCLUSION: Although the CUPI system was demonstrated to be the most appropriate HCC staging system for the studied population, the choice of an ideal system is a controversial subject, and future studies with larger numbers of patients are necessary for the validation of the CUPI system as the method of choice for other populations. Public Library of Science 2018-04-04 /pmc/articles/PMC5884519/ /pubmed/29617435 http://dx.doi.org/10.1371/journal.pone.0194922 Text en © 2018 Tannus et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tannus, R. K.
Almeida-Carvalho, S. R.
Loureiro-Matos, C. A.
Miziara-Gonzalez, A.
Salzedas-Netto, A. A.
Szejnfeld, D.
D'Ippolito, G.
Pereira-Lanzoni, V.
Souza-Silva, I.
Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems
title Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems
title_full Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems
title_fullStr Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems
title_full_unstemmed Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems
title_short Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems
title_sort evaluation of survival of patients with hepatocellular carcinoma: a comparative analysis of prognostic systems
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884519/
https://www.ncbi.nlm.nih.gov/pubmed/29617435
http://dx.doi.org/10.1371/journal.pone.0194922
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