Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation

Neurons require a nearly constant supply of ATP. Glucose is the predominant source of brain ATP, but the direct effects of prolonged glucose deprivation on neuronal viability and function remain unclear. In sparse rat hippocampal microcultures, neurons were surprisingly resilient to 16 h glucose rem...

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Detalles Bibliográficos
Autores principales: Sobieski, Courtney, Warikoo, Natasha, Shu, Hong-Jin, Mennerick, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884621/
https://www.ncbi.nlm.nih.gov/pubmed/29617444
http://dx.doi.org/10.1371/journal.pone.0195520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884621/
https://www.ncbi.nlm.nih.gov/pubmed/29617444
http://dx.doi.org/10.1371/journal.pone.0195520

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