Cargando…

Treatment of oral cancer using magnetized paclitaxel

N,N’-Bis(salicylidene)ethylenediamine iron (Fe(Salen)) is an anti-cancer agent with intrinsic magnetic property. Here, we covalently linked Fe(Salen) to paclitaxel (PTX), a widely used anti-cancer drug, to obtain a magnetized paclitaxel conjugate (M-PTX), which exhibited magnetic characteristics for...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakakaji, Rina, Umemura, Masanari, Mitsudo, Kenji, Kim, Jeong-Hwan, Hoshino, Yujiro, Sato, Itaru, Masuda, Takatsugu, Yamamoto, Masahiro, Kioi, Mitomu, Koizumi, Toshiyuki, Fujita, Takayuki, Yokoyama, Utako, Iida, Masaki, Sato, Motohiko, Sato, Hiroshi, Murofushi, Shoko, Shibata, Sayaka, Aoki, Ichio, Eguchi, Haruki, Tohnai, Iwai, Ishikawa, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884650/
https://www.ncbi.nlm.nih.gov/pubmed/29643995
http://dx.doi.org/10.18632/oncotarget.24570
_version_ 1783311857798348800
author Nakakaji, Rina
Umemura, Masanari
Mitsudo, Kenji
Kim, Jeong-Hwan
Hoshino, Yujiro
Sato, Itaru
Masuda, Takatsugu
Yamamoto, Masahiro
Kioi, Mitomu
Koizumi, Toshiyuki
Fujita, Takayuki
Yokoyama, Utako
Iida, Masaki
Sato, Motohiko
Sato, Hiroshi
Murofushi, Shoko
Shibata, Sayaka
Aoki, Ichio
Eguchi, Haruki
Tohnai, Iwai
Ishikawa, Yoshihiro
author_facet Nakakaji, Rina
Umemura, Masanari
Mitsudo, Kenji
Kim, Jeong-Hwan
Hoshino, Yujiro
Sato, Itaru
Masuda, Takatsugu
Yamamoto, Masahiro
Kioi, Mitomu
Koizumi, Toshiyuki
Fujita, Takayuki
Yokoyama, Utako
Iida, Masaki
Sato, Motohiko
Sato, Hiroshi
Murofushi, Shoko
Shibata, Sayaka
Aoki, Ichio
Eguchi, Haruki
Tohnai, Iwai
Ishikawa, Yoshihiro
author_sort Nakakaji, Rina
collection PubMed
description N,N’-Bis(salicylidene)ethylenediamine iron (Fe(Salen)) is an anti-cancer agent with intrinsic magnetic property. Here, we covalently linked Fe(Salen) to paclitaxel (PTX), a widely used anti-cancer drug, to obtain a magnetized paclitaxel conjugate (M-PTX), which exhibited magnetic characteristics for magnet-guided drug delivery and MRI visualization. M-PTX increased apoptosis and G2/M arrest of cultured human oral cancer cell lines in the same manner as PTX. Furthermore, marked contrast intensity was obtained in magnetic resonance imaging (MRI) of M-PTX. In a mouse oral cancer model, a permanent magnet placed on the body surface adjacent to the tumor resulted in distinct accumulation of M-PTX, and the anti-cancer effect was greater than that of M-PTX without the magnet. We believe that this strategy may improve future cancer chemotherapy by providing conventional anti-cancer drugs with novel functionalities such as magnet-guided drug delivery or MRI-based visualization/quantitation of drug distribution.
format Online
Article
Text
id pubmed-5884650
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-58846502018-04-11 Treatment of oral cancer using magnetized paclitaxel Nakakaji, Rina Umemura, Masanari Mitsudo, Kenji Kim, Jeong-Hwan Hoshino, Yujiro Sato, Itaru Masuda, Takatsugu Yamamoto, Masahiro Kioi, Mitomu Koizumi, Toshiyuki Fujita, Takayuki Yokoyama, Utako Iida, Masaki Sato, Motohiko Sato, Hiroshi Murofushi, Shoko Shibata, Sayaka Aoki, Ichio Eguchi, Haruki Tohnai, Iwai Ishikawa, Yoshihiro Oncotarget Research Paper N,N’-Bis(salicylidene)ethylenediamine iron (Fe(Salen)) is an anti-cancer agent with intrinsic magnetic property. Here, we covalently linked Fe(Salen) to paclitaxel (PTX), a widely used anti-cancer drug, to obtain a magnetized paclitaxel conjugate (M-PTX), which exhibited magnetic characteristics for magnet-guided drug delivery and MRI visualization. M-PTX increased apoptosis and G2/M arrest of cultured human oral cancer cell lines in the same manner as PTX. Furthermore, marked contrast intensity was obtained in magnetic resonance imaging (MRI) of M-PTX. In a mouse oral cancer model, a permanent magnet placed on the body surface adjacent to the tumor resulted in distinct accumulation of M-PTX, and the anti-cancer effect was greater than that of M-PTX without the magnet. We believe that this strategy may improve future cancer chemotherapy by providing conventional anti-cancer drugs with novel functionalities such as magnet-guided drug delivery or MRI-based visualization/quantitation of drug distribution. Impact Journals LLC 2018-02-26 /pmc/articles/PMC5884650/ /pubmed/29643995 http://dx.doi.org/10.18632/oncotarget.24570 Text en Copyright: © 2018 Nakakaji et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Nakakaji, Rina
Umemura, Masanari
Mitsudo, Kenji
Kim, Jeong-Hwan
Hoshino, Yujiro
Sato, Itaru
Masuda, Takatsugu
Yamamoto, Masahiro
Kioi, Mitomu
Koizumi, Toshiyuki
Fujita, Takayuki
Yokoyama, Utako
Iida, Masaki
Sato, Motohiko
Sato, Hiroshi
Murofushi, Shoko
Shibata, Sayaka
Aoki, Ichio
Eguchi, Haruki
Tohnai, Iwai
Ishikawa, Yoshihiro
Treatment of oral cancer using magnetized paclitaxel
title Treatment of oral cancer using magnetized paclitaxel
title_full Treatment of oral cancer using magnetized paclitaxel
title_fullStr Treatment of oral cancer using magnetized paclitaxel
title_full_unstemmed Treatment of oral cancer using magnetized paclitaxel
title_short Treatment of oral cancer using magnetized paclitaxel
title_sort treatment of oral cancer using magnetized paclitaxel
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884650/
https://www.ncbi.nlm.nih.gov/pubmed/29643995
http://dx.doi.org/10.18632/oncotarget.24570
work_keys_str_mv AT nakakajirina treatmentoforalcancerusingmagnetizedpaclitaxel
AT umemuramasanari treatmentoforalcancerusingmagnetizedpaclitaxel
AT mitsudokenji treatmentoforalcancerusingmagnetizedpaclitaxel
AT kimjeonghwan treatmentoforalcancerusingmagnetizedpaclitaxel
AT hoshinoyujiro treatmentoforalcancerusingmagnetizedpaclitaxel
AT satoitaru treatmentoforalcancerusingmagnetizedpaclitaxel
AT masudatakatsugu treatmentoforalcancerusingmagnetizedpaclitaxel
AT yamamotomasahiro treatmentoforalcancerusingmagnetizedpaclitaxel
AT kioimitomu treatmentoforalcancerusingmagnetizedpaclitaxel
AT koizumitoshiyuki treatmentoforalcancerusingmagnetizedpaclitaxel
AT fujitatakayuki treatmentoforalcancerusingmagnetizedpaclitaxel
AT yokoyamautako treatmentoforalcancerusingmagnetizedpaclitaxel
AT iidamasaki treatmentoforalcancerusingmagnetizedpaclitaxel
AT satomotohiko treatmentoforalcancerusingmagnetizedpaclitaxel
AT satohiroshi treatmentoforalcancerusingmagnetizedpaclitaxel
AT murofushishoko treatmentoforalcancerusingmagnetizedpaclitaxel
AT shibatasayaka treatmentoforalcancerusingmagnetizedpaclitaxel
AT aokiichio treatmentoforalcancerusingmagnetizedpaclitaxel
AT eguchiharuki treatmentoforalcancerusingmagnetizedpaclitaxel
AT tohnaiiwai treatmentoforalcancerusingmagnetizedpaclitaxel
AT ishikawayoshihiro treatmentoforalcancerusingmagnetizedpaclitaxel