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Value-based genomics

Advancements in next-generation sequencing have greatly enhanced the development of biomarker-driven cancer therapies. The affordability and availability of next-generation sequencers have allowed for the commercialization of next-generation sequencing platforms that have found widespread use for cl...

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Detalles Bibliográficos
Autores principales: Gong, Jun, Pan, Kathy, Fakih, Marwan, Pal, Sumanta, Salgia, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884665/
https://www.ncbi.nlm.nih.gov/pubmed/29644010
http://dx.doi.org/10.18632/oncotarget.24353
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author Gong, Jun
Pan, Kathy
Fakih, Marwan
Pal, Sumanta
Salgia, Ravi
author_facet Gong, Jun
Pan, Kathy
Fakih, Marwan
Pal, Sumanta
Salgia, Ravi
author_sort Gong, Jun
collection PubMed
description Advancements in next-generation sequencing have greatly enhanced the development of biomarker-driven cancer therapies. The affordability and availability of next-generation sequencers have allowed for the commercialization of next-generation sequencing platforms that have found widespread use for clinical-decision making and research purposes. Despite the greater availability of tumor molecular profiling by next-generation sequencing at our doorsteps, the achievement of value-based care, or improving patient outcomes while reducing overall costs or risks, in the era of precision oncology remains a looming challenge. In this review, we highlight available data through a pre-established and conceptualized framework for evaluating value-based medicine to assess the cost (efficiency), clinical benefit (effectiveness), and toxicity (safety) of genomic profiling in cancer care. We also provide perspectives on future directions of next-generation sequencing from targeted panels to whole-exome or whole-genome sequencing and describe potential strategies needed to attain value-based genomics.
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spelling pubmed-58846652018-04-11 Value-based genomics Gong, Jun Pan, Kathy Fakih, Marwan Pal, Sumanta Salgia, Ravi Oncotarget Review Advancements in next-generation sequencing have greatly enhanced the development of biomarker-driven cancer therapies. The affordability and availability of next-generation sequencers have allowed for the commercialization of next-generation sequencing platforms that have found widespread use for clinical-decision making and research purposes. Despite the greater availability of tumor molecular profiling by next-generation sequencing at our doorsteps, the achievement of value-based care, or improving patient outcomes while reducing overall costs or risks, in the era of precision oncology remains a looming challenge. In this review, we highlight available data through a pre-established and conceptualized framework for evaluating value-based medicine to assess the cost (efficiency), clinical benefit (effectiveness), and toxicity (safety) of genomic profiling in cancer care. We also provide perspectives on future directions of next-generation sequencing from targeted panels to whole-exome or whole-genome sequencing and describe potential strategies needed to attain value-based genomics. Impact Journals LLC 2018-01-30 /pmc/articles/PMC5884665/ /pubmed/29644010 http://dx.doi.org/10.18632/oncotarget.24353 Text en Copyright: © 2018 Gong et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Gong, Jun
Pan, Kathy
Fakih, Marwan
Pal, Sumanta
Salgia, Ravi
Value-based genomics
title Value-based genomics
title_full Value-based genomics
title_fullStr Value-based genomics
title_full_unstemmed Value-based genomics
title_short Value-based genomics
title_sort value-based genomics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884665/
https://www.ncbi.nlm.nih.gov/pubmed/29644010
http://dx.doi.org/10.18632/oncotarget.24353
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