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Sumoylation promotes optimal APC/C activation and timely anaphase

The Anaphase Promoting Complex/Cyclosome (APC/C) is a ubiquitin E3 ligase that functions as the gatekeeper to mitotic exit. APC/C activity is controlled by an interplay of multiple pathways during mitosis, including the spindle assembly checkpoint (SAC), that are not yet fully understood. Here, we s...

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Detalles Bibliográficos
Autores principales: Lee, Christine C, Li, Bing, Yu, Hongtao, Matunis, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884673/
https://www.ncbi.nlm.nih.gov/pubmed/29517484
http://dx.doi.org/10.7554/eLife.29539

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