Discovery of PACAP and its receptors in the brain

Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP. Because of the high homology of the amino acid sequences of...

Descripción completa

Detalles Bibliográficos
Autores principales: Hirabayashi, Takahiro, Nakamachi, Tomoya, Shioda, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884755/
https://www.ncbi.nlm.nih.gov/pubmed/29619773
http://dx.doi.org/10.1186/s10194-018-0855-1
_version_ 1783311868413083648
author Hirabayashi, Takahiro
Nakamachi, Tomoya
Shioda, Seiji
author_facet Hirabayashi, Takahiro
Nakamachi, Tomoya
Shioda, Seiji
author_sort Hirabayashi, Takahiro
collection PubMed
description Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP. Because of the high homology of the amino acid sequences of PACAP and VIP, these peptides share three class B-G-protein coupled receptors: the PAC1-Receptor (PAC1-R), the VPAC1-Receptor (VPAC1-R) and VPAC2-Receptor (VPAC2-R). These receptors have high homology to each other, and their high homology is utilized for these discoveries. This review provides mainly an overview of the history of the discovery of PACAP and its three receptors.
format Online
Article
Text
id pubmed-5884755
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer Milan
record_format MEDLINE/PubMed
spelling pubmed-58847552018-04-11 Discovery of PACAP and its receptors in the brain Hirabayashi, Takahiro Nakamachi, Tomoya Shioda, Seiji J Headache Pain Review Article Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP. Because of the high homology of the amino acid sequences of PACAP and VIP, these peptides share three class B-G-protein coupled receptors: the PAC1-Receptor (PAC1-R), the VPAC1-Receptor (VPAC1-R) and VPAC2-Receptor (VPAC2-R). These receptors have high homology to each other, and their high homology is utilized for these discoveries. This review provides mainly an overview of the history of the discovery of PACAP and its three receptors. Springer Milan 2018-04-04 /pmc/articles/PMC5884755/ /pubmed/29619773 http://dx.doi.org/10.1186/s10194-018-0855-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Hirabayashi, Takahiro
Nakamachi, Tomoya
Shioda, Seiji
Discovery of PACAP and its receptors in the brain
title Discovery of PACAP and its receptors in the brain
title_full Discovery of PACAP and its receptors in the brain
title_fullStr Discovery of PACAP and its receptors in the brain
title_full_unstemmed Discovery of PACAP and its receptors in the brain
title_short Discovery of PACAP and its receptors in the brain
title_sort discovery of pacap and its receptors in the brain
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884755/
https://www.ncbi.nlm.nih.gov/pubmed/29619773
http://dx.doi.org/10.1186/s10194-018-0855-1
work_keys_str_mv AT hirabayashitakahiro discoveryofpacapanditsreceptorsinthebrain
AT nakamachitomoya discoveryofpacapanditsreceptorsinthebrain
AT shiodaseiji discoveryofpacapanditsreceptorsinthebrain

Ejemplares similares