ETV2-TET1/TET2 Complexes Induce Endothelial Cell-Specific Robo4 Expression via Promoter Demethylation

Although transcription factors regulating endothelial cell (EC)-specific gene expression have been identified, it is not known how those factors induce EC-specificity. We previously reported that DNA hypomethylation of the proximal promoter elicits EC-specific expression of Roundabout4 (Robo4). Howe...

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Detalles Bibliográficos
Autores principales: Tanaka, Toru, Izawa, Kohei, Maniwa, Yusuke, Okamura, Maki, Okada, Atsumasa, Yamaguchi, Tomoko, Shirakura, Keisuke, Maekawa, Naoki, Matsui, Hayato, Ishimoto, Kenji, Hino, Nobumasa, Nakagawa, Osamu, Aird, William C., Mizuguchi, Hiroyuki, Kawabata, Kenji, Doi, Takefumi, Okada, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884809/
https://www.ncbi.nlm.nih.gov/pubmed/29618782
http://dx.doi.org/10.1038/s41598-018-23937-8

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