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Network approach of the conformational change of c-Src, a tyrosine kinase, by molecular dynamics simulation
Non-receptor tyrosine kinase c-Src plays a critical role in numerous cellular signalling pathways. Activation of c-Src from its inactive to the active state involves large-scale conformational changes, and is controlled by the phosphorylation state of two major phosphorylation sites, Tyr416 and Tyr5...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884825/ https://www.ncbi.nlm.nih.gov/pubmed/29618744 http://dx.doi.org/10.1038/s41598-018-23964-5 |