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Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy

Our aim is to study the dynamics of pupillary abnormalities in varying severity of diabetic retinopathy. A non-interventional case-control study with 405 eyes of 244 subjects with diabetes, and 41 eyes of 26 subjects with no history of diabetes was done. Diabetes group was classified according to re...

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Autores principales: Jain, Mukesh, Devan, Sandeep, Jaisankar, Durgasri, Swaminathan, Gayathri, Pardhan, Shahina, Raman, Rajiv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884827/
https://www.ncbi.nlm.nih.gov/pubmed/29618794
http://dx.doi.org/10.1038/s41598-018-24015-9
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author Jain, Mukesh
Devan, Sandeep
Jaisankar, Durgasri
Swaminathan, Gayathri
Pardhan, Shahina
Raman, Rajiv
author_facet Jain, Mukesh
Devan, Sandeep
Jaisankar, Durgasri
Swaminathan, Gayathri
Pardhan, Shahina
Raman, Rajiv
author_sort Jain, Mukesh
collection PubMed
description Our aim is to study the dynamics of pupillary abnormalities in varying severity of diabetic retinopathy. A non-interventional case-control study with 405 eyes of 244 subjects with diabetes, and 41 eyes of 26 subjects with no history of diabetes was done. Diabetes group was classified according to retinopathy severity: no retinopathy, mild non-proliferative diabetic retinopathy (NPDR), moderate NPDR, severe NPDR and proliferative diabetic retinopathy (PDR). After dark adaptation, pupil size and flashlight response were captured with an infrared camera. Baseline Pupil Diameter (BPD), Amplitude of Pupillary Constriction (APC), Velocity of Pupillary Constriction (VPC) and Velocity of Pupillary Dilatation (VPD). Compared to controls, mean BPD decreased with increasing severity of diabetic retinopathy. Mean APC in control group was 1.73 ± 0.37 mm and reduced in mild NPDR (1.57 ± 0.39, p = 1.000), moderate NPDR (1.51 ± 0.44, p = 0.152) and found to be significant reduced in severe NPDR (1.43 ± 0.48, p = 0.001) and PDR (1.29 ± 0.43, p = 0.008). Compared to controls, mean VPC decreased progressively with increasing severity of retinopathy, with a maximal difference in the PDR group. Mean VPD as compared to the control group was significantly reduced in the no DR (p = 0.03), mild NPDR (p = 0.038), moderate NPDR (p = 0.05), PDR group (p = 0.02). We found pupillary dynamics are abnormal in early stages of diabetic retinopathy and progress with increasing retinopathy severity.
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spelling pubmed-58848272018-04-09 Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy Jain, Mukesh Devan, Sandeep Jaisankar, Durgasri Swaminathan, Gayathri Pardhan, Shahina Raman, Rajiv Sci Rep Article Our aim is to study the dynamics of pupillary abnormalities in varying severity of diabetic retinopathy. A non-interventional case-control study with 405 eyes of 244 subjects with diabetes, and 41 eyes of 26 subjects with no history of diabetes was done. Diabetes group was classified according to retinopathy severity: no retinopathy, mild non-proliferative diabetic retinopathy (NPDR), moderate NPDR, severe NPDR and proliferative diabetic retinopathy (PDR). After dark adaptation, pupil size and flashlight response were captured with an infrared camera. Baseline Pupil Diameter (BPD), Amplitude of Pupillary Constriction (APC), Velocity of Pupillary Constriction (VPC) and Velocity of Pupillary Dilatation (VPD). Compared to controls, mean BPD decreased with increasing severity of diabetic retinopathy. Mean APC in control group was 1.73 ± 0.37 mm and reduced in mild NPDR (1.57 ± 0.39, p = 1.000), moderate NPDR (1.51 ± 0.44, p = 0.152) and found to be significant reduced in severe NPDR (1.43 ± 0.48, p = 0.001) and PDR (1.29 ± 0.43, p = 0.008). Compared to controls, mean VPC decreased progressively with increasing severity of retinopathy, with a maximal difference in the PDR group. Mean VPD as compared to the control group was significantly reduced in the no DR (p = 0.03), mild NPDR (p = 0.038), moderate NPDR (p = 0.05), PDR group (p = 0.02). We found pupillary dynamics are abnormal in early stages of diabetic retinopathy and progress with increasing retinopathy severity. Nature Publishing Group UK 2018-04-04 /pmc/articles/PMC5884827/ /pubmed/29618794 http://dx.doi.org/10.1038/s41598-018-24015-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jain, Mukesh
Devan, Sandeep
Jaisankar, Durgasri
Swaminathan, Gayathri
Pardhan, Shahina
Raman, Rajiv
Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy
title Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy
title_full Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy
title_fullStr Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy
title_full_unstemmed Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy
title_short Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy
title_sort pupillary abnormalities with varying severity of diabetic retinopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884827/
https://www.ncbi.nlm.nih.gov/pubmed/29618794
http://dx.doi.org/10.1038/s41598-018-24015-9
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