Cargando…

Single Administration of HBK-15—a Triple 5-HT(1A), 5-HT(7), and 5-HT(3) Receptor Antagonist—Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone

Studies suggest that the blockade of 5-HT(1A), 5-HT(7), and 5-HT(3) receptor may increase the speed of antidepressant response. 1-[(2,6-Dimethylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-14) and 1-[(2-chloro-6-methylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydroc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pytka, Karolina, Głuch-Lutwin, Monika, Kotańska, Magdalena, Waszkielewicz, Anna, Kij, Agnieszka, Walczak, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884906/ https://www.ncbi.nlm.nih.gov/pubmed/28550529 http://dx.doi.org/10.1007/s12035-017-0605-4

Ejemplares similares

HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats
por: Pytka, Karolina, et al.
Publicado: (2016)

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT(1A) and 5-HT(7) Antagonists in Animal Models
por: Pytka, Karolina, et al.
Publicado: (2015)

HBK-17, a 5-HT(1A) Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling
por: Pytka, Karolina, et al.
Publicado: (2018)

Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT(1A) and D(2) Receptors
por: Sałaciak, Kinga, et al.
Publicado: (2021)

Dual Molecules Targeting 5-HT(6) and GABA-A Receptors as a New Approach to Combat Depression Associated with Neuroinflammation
por: Marcinkowska, Monika, et al.
Publicado: (2023)

5-HT(4) Receptors Are Not Involved in the Effects of Fluoxetine in the Corticosterone Model of Depression
por: Amigo, Josep, et al.
Publicado: (2021)

The role of 5-HT receptors in depression
por: Yohn, Christine N., et al.
Publicado: (2017)

5-HT1A agonists, 5-HT3 antagonists and benzodiazepines : their comparative behavioural pharmacology /
Publicado: (1991)

Superiority of the Triple-Acting 5-HT(6)R/5-HT(3)R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT(6)R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats
por: Grychowska, Katarzyna, et al.
Publicado: (2023)

Changes of Serotonin (5-HT), 5-HT2A Receptor, and 5-HT Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression
por: Liu, Mei-Yan, et al.
Publicado: (2015)

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT
por: Sia, Tiong C., et al.
Publicado: (2013)

Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?
por: Spencer, Nick J.
Publicado: (2015)

Distribution of 5-HT(3), 5-HT(4), and 5-HT(7) Receptors Along the Human Colon
por: Yaakob, Nor S, et al.
Publicado: (2015)

Metabolic and Cardiovascular Benefits and Risks of EMD386088—A 5-HT(6) Receptor Partial Agonist and Dopamine Transporter Inhibitor
por: Kotańska, Magdalena, et al.
Publicado: (2017)

Review: 5-HT(1), 5-HT(2), 5-HT(3) and 5-HT(7) Receptors and their Role in the Modulation of Pain Response in the Central Nervous System
por: Cortes-Altamirano, Jose Luis, et al.
Publicado: (2018)

Overcoming Depression with 5-HT(2A) Receptor Ligands
por: Zięba, Agata, et al.
Publicado: (2021)

ECT AND PLATELET 5HT UPTAKE IN MAJOR DEPRESSION
por: Dalal, P.K., et al.
Publicado: (1997)

HBK-14 and HBK-15 with antidepressant-like and/or memory-enhancing properties increase serotonin levels in the hippocampus after chronic treatment in mice
por: Pytka, Karolina, et al.
Publicado: (2016)

The selective 5-HT(1A) receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress
por: Głuch-Lutwin, Monika, et al.
Publicado: (2021)

The 5-HT(7) receptor antagonist SB 269970 ameliorates corticosterone-induced alterations in 5-HT(7) receptor-mediated modulation of GABAergic transmission in the rat dorsal raphe nucleus
por: Sowa, Joanna, et al.
Publicado: (2018)

Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats
por: Fijał, Katarzyna, et al.
Publicado: (2013)

Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease
por: Neumann, Joachim, et al.
Publicado: (2023)

Conservation of 5-HT(1A) receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis
por: Araragi, Naozumi, et al.
Publicado: (2013)

Azologization of serotonin 5-HT(3) receptor antagonists
por: Rustler, Karin, et al.
Publicado: (2019)

Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT(1A) receptor partial agonists
por: Partyka, Anna, et al.
Publicado: (2020)

Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2017)

Agonists and antagonists induce different palonosetron dissociation rates in 5-HT(3)A and 5-HT(3)AB receptors()
por: Lummis, Sarah C.R., et al.
Publicado: (2013)

Human 5–HT(4) and 5–HT(7) Receptor Splice Variants: Are they Important?
por: Coupar, Ian M, et al.
Publicado: (2007)

Discriminating between 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, AJ, et al.
Publicado: (2013)

Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission
por: Sengupta, Ayesha, et al.
Publicado: (2017)

5-HT(2A), 5-HT(1B/D), 5HT(3) and 5-HT(7) receptors as mediators of serotonin-induced direct contractile response of bovine airway smooth muscle
por: Da Costa Guevara, Darwin, et al.
Publicado: (2021)

Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT(2A) and 5-HT(2B) receptors in chondrocytes
por: Hori, Ayaka, et al.
Publicado: (2017)

5-HT(3) Receptors
por: Lummis, Sarah C. R.
Publicado: (2012)

Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling
por: Chang, Kuo-Jung, et al.
Publicado: (2018)

5-HT and Intraplatelet 5-HT: a potential upstream regulator of YAP in liver regeneration
por: He, Chao, et al.
Publicado: (2019)

Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT(3) and 5-HT(6) Receptor Antagonist with Antipsychotic and Procognitive Properties
por: Zajdel, Paweł, et al.
Publicado: (2021)

ACTIVE PLATELET 5-HT UPTAKE IN DEPRESSIVES TREATED WITH IMPRAMINE AND ECT
por: Dalal, P.K., et al.
Publicado: (1998)

Translating the promise of 5HT(4) receptor agonists for the treatment of depression
por: Murphy, Susannah E, et al.
Publicado: (2021)

Dual 5-HT(3) and 5-HT(6) Receptor Antagonist FPPQ Normalizes Phencyclidine-Induced Disruption of Brain Oscillatory Activity in Rats
por: Castañé, Anna, et al.
Publicado: (2022)

Receptor–Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_a2v5m3ujt3iaub9uaoemu4fd52