Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening

Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular monomeric heme-containing enzyme that catalyzes the first and the rate limiting step in catabolism of tryptophan via the kynurenine (KYN) pathway, which plays a significant role in the proliferation and differentiation of T cells. IDO1 has bee...

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Detalles Bibliográficos
Autores principales: Zhang, Guoqing, Xing, Jing, Wang, Yulan, Wang, Lihao, Ye, Yan, Lu, Dong, Zhao, Jihui, Luo, Xiaomin, Zheng, Mingyue, Yan, Shiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884943/
https://www.ncbi.nlm.nih.gov/pubmed/29651242
http://dx.doi.org/10.3389/fphar.2018.00277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884943/
https://www.ncbi.nlm.nih.gov/pubmed/29651242
http://dx.doi.org/10.3389/fphar.2018.00277

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