Cargando…

Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening

Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular monomeric heme-containing enzyme that catalyzes the first and the rate limiting step in catabolism of tryptophan via the kynurenine (KYN) pathway, which plays a significant role in the proliferation and differentiation of T cells. IDO1 has bee...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Guoqing, Xing, Jing, Wang, Yulan, Wang, Lihao, Ye, Yan, Lu, Dong, Zhao, Jihui, Luo, Xiaomin, Zheng, Mingyue, Yan, Shiying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884943/ https://www.ncbi.nlm.nih.gov/pubmed/29651242 http://dx.doi.org/10.3389/fphar.2018.00277

Ejemplares similares

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening
por: Sari, Suat, et al.
Publicado: (2019)

Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation
por: Xu, Xi, et al.
Publicado: (2019)

Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening
por: Guo, Wei, et al.
Publicado: (2019)

Localization of Indoleamine 2,3-Dioxygenase-1 and Indoleamine 2,3-Dioxygenase-2 at the Human Maternal-Fetal Interface
por: Kudo, Yoshiki, et al.
Publicado: (2020)

Indoleamine 2,3 dioxygenase 1 immobilization on magnetic nanoparticles for screening inhibitors from coffee
por: Liu, Zhuoting, et al.
Publicado: (2023)

Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors
por: Zulfiqar, Bilal, et al.
Publicado: (2017)

Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase
por: Yoshioka, Saeko, et al.
Publicado: (2022)

The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancer
por: Gao, Yan-Fang, et al.
Publicado: (2009)

Indoleamine 2,3-dioxygenase 1 promotes osteosarcoma progression by regulating tumor-derived exosomal miRNA hsa-miR-23a-3p
por: Yang, Dan, et al.
Publicado: (2023)

Editorial: Targeting Indoleamine 2,3-dioxygenases and Tryptophan Dioxygenase for Cancer Immunotherapy
por: Brochez, Lieve, et al.
Publicado: (2021)

Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product
por: Zhao, Hongchuan, et al.
Publicado: (2019)

Targeting the indoleamine 2,3-dioxygenase pathway in cancer
por: Moon, Yong Wha, et al.
Publicado: (2015)

Hypoxia enhances indoleamine 2,3-dioxygenase production in dendritic cells
por: Song, Xiang, et al.
Publicado: (2018)

Indoleamine 2, 3-dioxygenase 1 inhibitory compounds from natural sources
por: Tan, Ying, et al.
Publicado: (2022)

Design and Synthesis of Indoleamine 2,3-Dioxygenase 1 Inhibitors and Evaluation of Their Use as Anti-Tumor Agents
por: Wen, Hui, et al.
Publicado: (2019)

Computational study on new natural compound inhibitors of indoleamine 2,3-dioxygenase 1
por: Jiang, Shanshan, et al.
Publicado: (2020)

Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1
por: Hu, Mingxing, et al.
Publicado: (2020)

Forty‐three key gene expressions involved in the effect of indoleamine 2,3‐dioxygenase 1 expression on cancer prognosis may be a potential indoleamine 2,3‐dioxygenase 1 inhibitor biomarker
por: Li, Weirui, et al.
Publicado: (2021)

The Mechanism of Substrate Inhibition in Human Indoleamine 2,3-Dioxygenase
por: Efimov, Igor, et al.
Publicado: (2012)

Indoleamine-2,3-dioxygenase activity induces neutrophil apoptosis
por: Van der Sluijs, K, et al.
Publicado: (2011)

Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia
por: Padberg, Jan-Sören, et al.
Publicado: (2012)

The role of placental indoleamine 2,3-dioxygenase in human pregnancy
por: Kudo, Yoshiki
Publicado: (2013)

Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry
por: Coletti, Alice, et al.
Publicado: (2017)

Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?
por: Mellor, Andrew L., et al.
Publicado: (2017)

Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract
por: Acovic, Aleksandar, et al.
Publicado: (2018)

Role of indoleamine 2,3-dioxygenase in testicular immune-privilege
por: Gualdoni, Gisela S., et al.
Publicado: (2019)

A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases
por: Zhou, Qihui, et al.
Publicado: (2021)

Comparison study of different indoleamine-2,3 dioxygenase inhibitors from the perspective of pharmacodynamic effects
por: Jiang, Xue, et al.
Publicado: (2020)

Expression and Prognostic Value of Indoleamine 2,3-dioxygenase in Pancreatic Cancer
por: Zhang, Tao, et al.
Publicado: (2017)

Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries
por: Xu, Lingyan, et al.
Publicado: (2021)

Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment
por: Dai, Jiajia, et al.
Publicado: (2022)

Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer
por: Chen, I-Chien, et al.
Publicado: (2016)

Spiro-Oxindole Skeleton Compounds Are Efficient Inhibitors for Indoleamine 2,3-Dioxygenase 1: An Attractive Target for Tumor Immunotherapy
por: Yan, Daojing, et al.
Publicado: (2022)

Indoleamine-2,3-dioxygenase 1/cyclooxygenase 2 expression prediction for adverse prognosis in colorectal cancer
por: Ma, Wen-Juan, et al.
Publicado: (2018)

Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model
por: Rojewska, Ewelina, et al.
Publicado: (2018)

Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
por: Lewis-Ballester, Ariel, et al.
Publicado: (2017)

What May Constrain the Success of Indoleamine 2,3-Dioxygenase 1 Inhibitors in Cancer Immunotherapy?
por: Eleftheriadis, Theodoros
Publicado: (2018)

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy
por: Tang, Kai, et al.
Publicado: (2021)

The kynurenine pathway implicated in patient delirium: possible indications for indoleamine 2,3 dioxygenase inhibitors
por: Heimberger, Amy B., et al.
Publicado: (2023)

Indoleamine 2,3-Dioxygenase in Human Hematopoietic Stem Cell Transplantation
por: Jürgens, Birgit, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_gdja5l1jp0rs1j8ati27ts6eoa