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The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer
Exosomes, small (30-150nm) extracellular vesicles of endocytic origin, are present in all body fluids of cancer patients. Tumor-derived exosomes, TEX, emerge as potentially promising non-invasive biomarkers of tumor progression and of immune cell dysfunction in cancer. Exosomes isolated from plasma...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Termedia Publishing House
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885072/ https://www.ncbi.nlm.nih.gov/pubmed/29628792 http://dx.doi.org/10.5114/wo.2018.73882 |
Sumario: | Exosomes, small (30-150nm) extracellular vesicles of endocytic origin, are present in all body fluids of cancer patients. Tumor-derived exosomes, TEX, emerge as potentially promising non-invasive biomarkers of tumor progression and of immune cell dysfunction in cancer. Exosomes isolated from plasma by size exclusion chromatography can be fractionated into TEX and non-TEX by immune capture on beads. Profiling of molecular and genetic contents of TEX shows that levels if immunosuppressive proteins, such as PD-L1, carried by TEX associate with disease progression. The data suggest that TEX have a to serve as tumor surrogates, while immune cell-derived exosomes might serve as biomarkers of immune dysfunction in cancer. |
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