The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer

Exosomes, small (30-150nm) extracellular vesicles of endocytic origin, are present in all body fluids of cancer patients. Tumor-derived exosomes, TEX, emerge as potentially promising non-invasive biomarkers of tumor progression and of immune cell dysfunction in cancer. Exosomes isolated from plasma...

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Detalles Bibliográficos
Autor principal: Whiteside, Theresa L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885072/
https://www.ncbi.nlm.nih.gov/pubmed/29628792
http://dx.doi.org/10.5114/wo.2018.73882
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author Whiteside, Theresa L.
author_facet Whiteside, Theresa L.
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description Exosomes, small (30-150nm) extracellular vesicles of endocytic origin, are present in all body fluids of cancer patients. Tumor-derived exosomes, TEX, emerge as potentially promising non-invasive biomarkers of tumor progression and of immune cell dysfunction in cancer. Exosomes isolated from plasma by size exclusion chromatography can be fractionated into TEX and non-TEX by immune capture on beads. Profiling of molecular and genetic contents of TEX shows that levels if immunosuppressive proteins, such as PD-L1, carried by TEX associate with disease progression. The data suggest that TEX have a to serve as tumor surrogates, while immune cell-derived exosomes might serve as biomarkers of immune dysfunction in cancer.
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spelling pubmed-58850722018-04-06 The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer Whiteside, Theresa L. Contemp Oncol (Pozn) Review Exosomes, small (30-150nm) extracellular vesicles of endocytic origin, are present in all body fluids of cancer patients. Tumor-derived exosomes, TEX, emerge as potentially promising non-invasive biomarkers of tumor progression and of immune cell dysfunction in cancer. Exosomes isolated from plasma by size exclusion chromatography can be fractionated into TEX and non-TEX by immune capture on beads. Profiling of molecular and genetic contents of TEX shows that levels if immunosuppressive proteins, such as PD-L1, carried by TEX associate with disease progression. The data suggest that TEX have a to serve as tumor surrogates, while immune cell-derived exosomes might serve as biomarkers of immune dysfunction in cancer. Termedia Publishing House 2018-03-05 2018-03 /pmc/articles/PMC5885072/ /pubmed/29628792 http://dx.doi.org/10.5114/wo.2018.73882 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Review
Whiteside, Theresa L.
The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer
title The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer
title_full The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer
title_fullStr The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer
title_full_unstemmed The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer
title_short The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer
title_sort emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885072/
https://www.ncbi.nlm.nih.gov/pubmed/29628792
http://dx.doi.org/10.5114/wo.2018.73882
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