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The sleep architecture of Saudi Arabian patients with Kleine-Levin syndrome
OBJECTIVES: To establish baseline sleep architecture during an acute attack of Kleine-Levin syndrome (KLS) in a cohort of Saudi Arabian KLS patients and compare these characteristics with other published cohorts. METHODS: This was a retrospective cohort study of the polysomnographic characteristics...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Saudi Medical Journal
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885119/ https://www.ncbi.nlm.nih.gov/pubmed/29332107 http://dx.doi.org/10.15537/smj.2018.1.21045 |
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author | Al Shareef, Saad M. Almeneessier, Aljohara S. Hammad, Omeima Smith, Richard M. BaHammam, Ahmed S. |
author_facet | Al Shareef, Saad M. Almeneessier, Aljohara S. Hammad, Omeima Smith, Richard M. BaHammam, Ahmed S. |
author_sort | Al Shareef, Saad M. |
collection | PubMed |
description | OBJECTIVES: To establish baseline sleep architecture during an acute attack of Kleine-Levin syndrome (KLS) in a cohort of Saudi Arabian KLS patients and compare these characteristics with other published cohorts. METHODS: This was a retrospective cohort study of the polysomnographic characteristics of 10 typical symptomatic Saudi Arabian KLS patients attending the University Sleep Disorders Center, King Saud University, Riyadh, Saudi Arabia between 2002 and 2015. Data were captured by nocturnal polysomnography during an acute attack of hypersomnia and compared with other published cohorts identified via a systematic literature search. RESULTS: Self-reported time asleep during episodes (11.1±6.7 hours) and recorded total sleep time (TST) (322.5±108.7 minutes) were generally shorter than other published cohorts. Sleep efficiency was poor at 75.0%±25.1%, with low relative amounts of rapid eye movement (REM) sleep (16.5±5.9% of TST) and deep non-REM sleep (stage N3; 10.5±6.0% of TST) and high relative amounts of non-REM sleep (stage N1; 7.0±4.3% of TST). The sleep architecture of Saudi Arabian KLS patients was similar to other published cohorts. CONCLUSIONS: Sleep architecture of our cohort was relatively normal and broadly similar to other published studies, the main features being low sleep efficiency and low relative amounts of REM and stage N3 sleep. Time-course polysomnography studies with functional imaging may be useful to further establish the exact pathophysiology of this disease. |
format | Online Article Text |
id | pubmed-5885119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Saudi Medical Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-58851192018-04-11 The sleep architecture of Saudi Arabian patients with Kleine-Levin syndrome Al Shareef, Saad M. Almeneessier, Aljohara S. Hammad, Omeima Smith, Richard M. BaHammam, Ahmed S. Saudi Med J Original Article OBJECTIVES: To establish baseline sleep architecture during an acute attack of Kleine-Levin syndrome (KLS) in a cohort of Saudi Arabian KLS patients and compare these characteristics with other published cohorts. METHODS: This was a retrospective cohort study of the polysomnographic characteristics of 10 typical symptomatic Saudi Arabian KLS patients attending the University Sleep Disorders Center, King Saud University, Riyadh, Saudi Arabia between 2002 and 2015. Data were captured by nocturnal polysomnography during an acute attack of hypersomnia and compared with other published cohorts identified via a systematic literature search. RESULTS: Self-reported time asleep during episodes (11.1±6.7 hours) and recorded total sleep time (TST) (322.5±108.7 minutes) were generally shorter than other published cohorts. Sleep efficiency was poor at 75.0%±25.1%, with low relative amounts of rapid eye movement (REM) sleep (16.5±5.9% of TST) and deep non-REM sleep (stage N3; 10.5±6.0% of TST) and high relative amounts of non-REM sleep (stage N1; 7.0±4.3% of TST). The sleep architecture of Saudi Arabian KLS patients was similar to other published cohorts. CONCLUSIONS: Sleep architecture of our cohort was relatively normal and broadly similar to other published studies, the main features being low sleep efficiency and low relative amounts of REM and stage N3 sleep. Time-course polysomnography studies with functional imaging may be useful to further establish the exact pathophysiology of this disease. Saudi Medical Journal 2018-01 /pmc/articles/PMC5885119/ /pubmed/29332107 http://dx.doi.org/10.15537/smj.2018.1.21045 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Al Shareef, Saad M. Almeneessier, Aljohara S. Hammad, Omeima Smith, Richard M. BaHammam, Ahmed S. The sleep architecture of Saudi Arabian patients with Kleine-Levin syndrome |
title | The sleep architecture of Saudi Arabian patients with Kleine-Levin syndrome |
title_full | The sleep architecture of Saudi Arabian patients with Kleine-Levin syndrome |
title_fullStr | The sleep architecture of Saudi Arabian patients with Kleine-Levin syndrome |
title_full_unstemmed | The sleep architecture of Saudi Arabian patients with Kleine-Levin syndrome |
title_short | The sleep architecture of Saudi Arabian patients with Kleine-Levin syndrome |
title_sort | sleep architecture of saudi arabian patients with kleine-levin syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885119/ https://www.ncbi.nlm.nih.gov/pubmed/29332107 http://dx.doi.org/10.15537/smj.2018.1.21045 |
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