Cargando…

Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum

OBJECTIVE: Existing information has shown that infants who are prenatally exposed to P. falciparum are susceptible to subsequent malaria infections. However, the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes has not been fully elucidated. This stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Sylvester, Boniphace, Gasarasi, Dinah B., Aboud, Said, Tarimo, Donath, Massawe, Siriel, Mpembeni, Rose, Swedberg, Gote
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885461/
https://www.ncbi.nlm.nih.gov/pubmed/29618382
http://dx.doi.org/10.1186/s13104-018-3339-0
_version_ 1783311993828016128
author Sylvester, Boniphace
Gasarasi, Dinah B.
Aboud, Said
Tarimo, Donath
Massawe, Siriel
Mpembeni, Rose
Swedberg, Gote
author_facet Sylvester, Boniphace
Gasarasi, Dinah B.
Aboud, Said
Tarimo, Donath
Massawe, Siriel
Mpembeni, Rose
Swedberg, Gote
author_sort Sylvester, Boniphace
collection PubMed
description OBJECTIVE: Existing information has shown that infants who are prenatally exposed to P. falciparum are susceptible to subsequent malaria infections. However, the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes has not been fully elucidated. This study is a component of a prospective cohort study for which initial results have been published. This component was designed to determine the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes in the first 24 months of life. A total of 215 infants were involved and monitored for clinical malaria episodes defined by fever (≥ 37 °C) and parasitaemia. The geometric mean parasite counts between exposed and unexposed infants were compared using independent samples t test. The effect of in utero exposure to P. falciparum on parasite density was assessed using binary logistic regression. RESULTS: The geometric mean parasite count per µl of blood during clinical malaria episodes in exposed infants was 24,889 (95% CI 18,286–31,490) while in unexposed infants it was 14,035 (95% CI 12,111–15,960), P < 0.05. Prenatal exposure to P. falciparum was associated with hyperparasitaemia during clinical malaria episodes (OR 7.04, 95% CI 2.31–21.74), while other factors were not significantly associated (P > 0.05).
format Online
Article
Text
id pubmed-5885461
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-58854612018-04-09 Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum Sylvester, Boniphace Gasarasi, Dinah B. Aboud, Said Tarimo, Donath Massawe, Siriel Mpembeni, Rose Swedberg, Gote BMC Res Notes Research Note OBJECTIVE: Existing information has shown that infants who are prenatally exposed to P. falciparum are susceptible to subsequent malaria infections. However, the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes has not been fully elucidated. This study is a component of a prospective cohort study for which initial results have been published. This component was designed to determine the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes in the first 24 months of life. A total of 215 infants were involved and monitored for clinical malaria episodes defined by fever (≥ 37 °C) and parasitaemia. The geometric mean parasite counts between exposed and unexposed infants were compared using independent samples t test. The effect of in utero exposure to P. falciparum on parasite density was assessed using binary logistic regression. RESULTS: The geometric mean parasite count per µl of blood during clinical malaria episodes in exposed infants was 24,889 (95% CI 18,286–31,490) while in unexposed infants it was 14,035 (95% CI 12,111–15,960), P < 0.05. Prenatal exposure to P. falciparum was associated with hyperparasitaemia during clinical malaria episodes (OR 7.04, 95% CI 2.31–21.74), while other factors were not significantly associated (P > 0.05). BioMed Central 2018-04-04 /pmc/articles/PMC5885461/ /pubmed/29618382 http://dx.doi.org/10.1186/s13104-018-3339-0 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Sylvester, Boniphace
Gasarasi, Dinah B.
Aboud, Said
Tarimo, Donath
Massawe, Siriel
Mpembeni, Rose
Swedberg, Gote
Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum
title Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum
title_full Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum
title_fullStr Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum
title_full_unstemmed Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum
title_short Hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to Plasmodium falciparum
title_sort hyperparasitaemia during clinical malaria episodes in infants aged 0–24 months and its association with in utero exposure to plasmodium falciparum
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885461/
https://www.ncbi.nlm.nih.gov/pubmed/29618382
http://dx.doi.org/10.1186/s13104-018-3339-0
work_keys_str_mv AT sylvesterboniphace hyperparasitaemiaduringclinicalmalariaepisodesininfantsaged024monthsanditsassociationwithinuteroexposuretoplasmodiumfalciparum
AT gasarasidinahb hyperparasitaemiaduringclinicalmalariaepisodesininfantsaged024monthsanditsassociationwithinuteroexposuretoplasmodiumfalciparum
AT aboudsaid hyperparasitaemiaduringclinicalmalariaepisodesininfantsaged024monthsanditsassociationwithinuteroexposuretoplasmodiumfalciparum
AT tarimodonath hyperparasitaemiaduringclinicalmalariaepisodesininfantsaged024monthsanditsassociationwithinuteroexposuretoplasmodiumfalciparum
AT massawesiriel hyperparasitaemiaduringclinicalmalariaepisodesininfantsaged024monthsanditsassociationwithinuteroexposuretoplasmodiumfalciparum
AT mpembenirose hyperparasitaemiaduringclinicalmalariaepisodesininfantsaged024monthsanditsassociationwithinuteroexposuretoplasmodiumfalciparum
AT swedberggote hyperparasitaemiaduringclinicalmalariaepisodesininfantsaged024monthsanditsassociationwithinuteroexposuretoplasmodiumfalciparum