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Glutaredoxins employ parallel monothiol–dithiol mechanisms to catalyze thiol–disulfide exchanges with protein disulfides

Glutaredoxins (Grxs) are a family of glutathione (GSH)-dependent thiol–disulfide oxidoreductases. They feature GSH-binding sites that directly connect the reversible redox chemistry of protein thiols to the abundant cellular nonprotein thiol pool GSSG/GSH. This work studied the pathways for oxidatio...

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Detalles Bibliográficos
Autores principales:	Ukuwela, Ashwinie A., Bush, Ashley I., Wedd, Anthony G., Xiao, Zhiguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885593/ https://www.ncbi.nlm.nih.gov/pubmed/29675162 http://dx.doi.org/10.1039/c7sc04416j

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