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Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett’s Esophagus

BACKGROUND/AIMS: Esophageal motor disorder (EMD) has been shown to be associated with gastroesophageal reflux disease (GERD). However, the association of EMD with a Barrett’s esophagus (BE) is controversial. Our objective was to evaluate whether the presence of EMD was an independent factor associat...

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Autores principales: Bazin, Camille, Benezech, Alban, Alessandrini, Marine, Grimaud, Jean-Charles, Vitton, Veronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Neurogastroenterology and Motility 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885720/
https://www.ncbi.nlm.nih.gov/pubmed/29605977
http://dx.doi.org/10.5056/jnm17090
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author Bazin, Camille
Benezech, Alban
Alessandrini, Marine
Grimaud, Jean-Charles
Vitton, Veronique
author_facet Bazin, Camille
Benezech, Alban
Alessandrini, Marine
Grimaud, Jean-Charles
Vitton, Veronique
author_sort Bazin, Camille
collection PubMed
description BACKGROUND/AIMS: Esophageal motor disorder (EMD) has been shown to be associated with gastroesophageal reflux disease (GERD). However, the association of EMD with a Barrett’s esophagus (BE) is controversial. Our objective was to evaluate whether the presence of EMD was an independent factor associated with BE. METHODS: A retrospective case-control study was conducted in GERD patients who all had oeso-gastroduodenal endoscopy and high-resolution esophageal manometry. The clinical data collected was known or potential risk factors for BE: male gender, smoking and alcohol consumption, age, body mass index, presence of hiatal hernia, frequency, and age of GERD. EMD were classified according to the Chicago classification into: ineffective motor syndrome, fragmented peristalsis and absence of peristalsis, lower esophageal sphincter hypotonia. RESULTS: Two hundred and one patients (101 in the GERD + BE group and 100 in the GERD without BE) were included. In univariate analysis, male gender, alcohol consumption, presence of hiatal hernia, and EMD appeared to be associated with the presence of BE. In a multivariate analysis, 3 independent factors were identified: the presence of EMD (odds ratio [OR], 3.99; 95% confidence interval [CI], 1.71–9.28; P = 0.001), the presence of hiatal hernia (OR, 5.60; 95% CI, 2.45–12.76; P < 0.001), Helicobacter pylori infection (OR, 0.08; 95% CI, 0.01–0.84; P = 0.035). CONCLUSIONS: The presence of EMD (particularly ineffective motor syndrome and lower esophageal sphincter hypotonia) is a strong independent associated factor of BE. Searching systematically for an EMD in patients suffering from GERD could be a new strategy to organize the endoscopic follow-up.
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spelling pubmed-58857202018-04-06 Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett’s Esophagus Bazin, Camille Benezech, Alban Alessandrini, Marine Grimaud, Jean-Charles Vitton, Veronique J Neurogastroenterol Motil Original Article BACKGROUND/AIMS: Esophageal motor disorder (EMD) has been shown to be associated with gastroesophageal reflux disease (GERD). However, the association of EMD with a Barrett’s esophagus (BE) is controversial. Our objective was to evaluate whether the presence of EMD was an independent factor associated with BE. METHODS: A retrospective case-control study was conducted in GERD patients who all had oeso-gastroduodenal endoscopy and high-resolution esophageal manometry. The clinical data collected was known or potential risk factors for BE: male gender, smoking and alcohol consumption, age, body mass index, presence of hiatal hernia, frequency, and age of GERD. EMD were classified according to the Chicago classification into: ineffective motor syndrome, fragmented peristalsis and absence of peristalsis, lower esophageal sphincter hypotonia. RESULTS: Two hundred and one patients (101 in the GERD + BE group and 100 in the GERD without BE) were included. In univariate analysis, male gender, alcohol consumption, presence of hiatal hernia, and EMD appeared to be associated with the presence of BE. In a multivariate analysis, 3 independent factors were identified: the presence of EMD (odds ratio [OR], 3.99; 95% confidence interval [CI], 1.71–9.28; P = 0.001), the presence of hiatal hernia (OR, 5.60; 95% CI, 2.45–12.76; P < 0.001), Helicobacter pylori infection (OR, 0.08; 95% CI, 0.01–0.84; P = 0.035). CONCLUSIONS: The presence of EMD (particularly ineffective motor syndrome and lower esophageal sphincter hypotonia) is a strong independent associated factor of BE. Searching systematically for an EMD in patients suffering from GERD could be a new strategy to organize the endoscopic follow-up. Korean Society of Neurogastroenterology and Motility 2018-04 2018-04-01 /pmc/articles/PMC5885720/ /pubmed/29605977 http://dx.doi.org/10.5056/jnm17090 Text en © 2018 The Korean Society of Neurogastroenterology and Motility This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bazin, Camille
Benezech, Alban
Alessandrini, Marine
Grimaud, Jean-Charles
Vitton, Veronique
Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett’s Esophagus
title Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett’s Esophagus
title_full Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett’s Esophagus
title_fullStr Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett’s Esophagus
title_full_unstemmed Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett’s Esophagus
title_short Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett’s Esophagus
title_sort esophageal motor disorders are a strong and independant associated factor of barrett’s esophagus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885720/
https://www.ncbi.nlm.nih.gov/pubmed/29605977
http://dx.doi.org/10.5056/jnm17090
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