Discordance for Cri du Chat Syndrome in a dichorionic–diamniotic twin pregnancy

We report on the prenatal diagnosis through array CGH of a dichorionic–diamniotic (DC/DA) twins discordant for Cri du Chat Syndrome. Structural anomalies on one of the twins lead to amniotic fluid sampling, which revealed a partial deletion on the short arm of the chromosome 5. Selective feticide of...

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Detalles Bibliográficos
Autores principales: González-Comadran, Mireia, Hernández Sánchez, José Luís, Rueda, Carolina, Ferriols, Elena, Prat, Maria, Rubio, Ricardo, Carreras, Ramón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886005/
https://www.ncbi.nlm.nih.gov/pubmed/29629308
http://dx.doi.org/10.1016/j.crwh.2015.07.003
Descripción
Sumario:We report on the prenatal diagnosis through array CGH of a dichorionic–diamniotic (DC/DA) twins discordant for Cri du Chat Syndrome. Structural anomalies on one of the twins lead to amniotic fluid sampling, which revealed a partial deletion on the short arm of the chromosome 5. Selective feticide of the affected twin was performed at 34 + 1 weeks' and elective Cesarean section at 37 + 2 weeks. Postnatal cytogenetic analysis confirmed pre-natal genetic findings.

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