Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size

C9orf72 expansions are the most common genetic cause of FTLD and MND identified to date. Although being intronic, the expansion is translated into five different dipeptide repeat proteins (DPRs) that accumulate within patients’ neurons. Attempts have been made to model DPRs in cell and animals. Howe...

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Detalles Bibliográficos
Autores principales: Bennion Callister, Janis, Ryan, Sarah, Sim, Joan, Rollinson, Sara, Pickering-Brown, Stuart M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886041/
https://www.ncbi.nlm.nih.gov/pubmed/27798094
http://dx.doi.org/10.1093/hmg/ddw327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886041/
https://www.ncbi.nlm.nih.gov/pubmed/27798094
http://dx.doi.org/10.1093/hmg/ddw327

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