Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans

A hexanucleotide repeat expansion mutation in the C9orf72 gene represents a prevalent genetic cause of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Non-canonical translation of this repeat gives rise to several distinct dipeptide prot...

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Detalles Bibliográficos
Autores principales: Rudich, Paige, Snoznik, Carley, Watkins, Simon C, Monaghan, John, Pandey, Udai Bhan, Lamitina, S Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886095/
https://www.ncbi.nlm.nih.gov/pubmed/29036691
http://dx.doi.org/10.1093/hmg/ddx372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886095/
https://www.ncbi.nlm.nih.gov/pubmed/29036691
http://dx.doi.org/10.1093/hmg/ddx372

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