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Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma

PURPOSE: To independently validate the performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index in diagnosing and predicting early glaucoma. METHODS: Data of 118 normal subjects (118 eyes) and 96 subjects (96 eyes) with early glaucoma defined as visual field mean...

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Autores principales: Mwanza, Jean-Claude, Lee, Gary, Budenz, Donald L., Warren, Joshua L., Wall, Michael, Artes, Paul H., Callan, Thomas M., Flanagan, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886105/
https://www.ncbi.nlm.nih.gov/pubmed/29629238
http://dx.doi.org/10.1167/tvst.7.2.16
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author Mwanza, Jean-Claude
Lee, Gary
Budenz, Donald L.
Warren, Joshua L.
Wall, Michael
Artes, Paul H.
Callan, Thomas M.
Flanagan, John G.
author_facet Mwanza, Jean-Claude
Lee, Gary
Budenz, Donald L.
Warren, Joshua L.
Wall, Michael
Artes, Paul H.
Callan, Thomas M.
Flanagan, John G.
author_sort Mwanza, Jean-Claude
collection PubMed
description PURPOSE: To independently validate the performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index in diagnosing and predicting early glaucoma. METHODS: Data of 118 normal subjects (118 eyes) and 96 subjects (96 eyes) with early glaucoma defined as visual field mean deviation (MD) greater than −4 decibels (dB), aged 40 to 80 years, and who were enrolled in the Full-Threshold Testing Size III, V, VI comparison study were used in this study. CIRRUS OCT average and quadrants' retinal nerve fiber layer (RNFL); optic disc vertical cup-to-disc ratio (VCDR), cup-to-disc area ratio, and rim area; and average, minimum, and six sectoral ganglion cell-inner plexiform layer (GCIPL) measurements were run through the UNC OCT Index algorithm. Area under the receiver operating characteristic curve (AUC) and sensitivities at 95% and 99% specificity were calculated and compared between single parameters and the UNC OCT Index. RESULTS: Mean age was 60.1 ± 11.0 years for normal subjects and 66.5 ± 8.1 years for glaucoma patients (P < 0.001). MD was 0.29 ± 1.04 dB and −1.30 ± 1.35 dB in normal and glaucomatous eyes (P < 0.001), respectively. The AUC of the UNC OCT Index was 0.96. The best single metrics when compared to the UNC OCT Index were VCDR (0.93, P = 0.054), average RNFL (0.92, P = 0.014), and minimum GCIPL (0.91, P = 0.009). The sensitivities at 95% and 99% specificity were 85.4% and 76.0% (UNC OCT Index), 71.9% and 62.5% (VCDR, all P < 0.001), 64.6% and 53.1% (average RNFL, all P < 0.001), and 66.7% and 58.3% (minimum GCIPL, all P < 0.001), respectively. CONCLUSIONS: The findings confirm that the UNC OCT Index may provide improved diagnostic perforce over that of single OCT parameters and may be a good tool for detection of early glaucoma. TRANSLATIONAL RELEVANCE: The UNC OCT Index algorithm may be incorporated easily into routine clinical practice and be useful for detecting early glaucoma.
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spelling pubmed-58861052018-04-06 Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma Mwanza, Jean-Claude Lee, Gary Budenz, Donald L. Warren, Joshua L. Wall, Michael Artes, Paul H. Callan, Thomas M. Flanagan, John G. Transl Vis Sci Technol Articles PURPOSE: To independently validate the performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index in diagnosing and predicting early glaucoma. METHODS: Data of 118 normal subjects (118 eyes) and 96 subjects (96 eyes) with early glaucoma defined as visual field mean deviation (MD) greater than −4 decibels (dB), aged 40 to 80 years, and who were enrolled in the Full-Threshold Testing Size III, V, VI comparison study were used in this study. CIRRUS OCT average and quadrants' retinal nerve fiber layer (RNFL); optic disc vertical cup-to-disc ratio (VCDR), cup-to-disc area ratio, and rim area; and average, minimum, and six sectoral ganglion cell-inner plexiform layer (GCIPL) measurements were run through the UNC OCT Index algorithm. Area under the receiver operating characteristic curve (AUC) and sensitivities at 95% and 99% specificity were calculated and compared between single parameters and the UNC OCT Index. RESULTS: Mean age was 60.1 ± 11.0 years for normal subjects and 66.5 ± 8.1 years for glaucoma patients (P < 0.001). MD was 0.29 ± 1.04 dB and −1.30 ± 1.35 dB in normal and glaucomatous eyes (P < 0.001), respectively. The AUC of the UNC OCT Index was 0.96. The best single metrics when compared to the UNC OCT Index were VCDR (0.93, P = 0.054), average RNFL (0.92, P = 0.014), and minimum GCIPL (0.91, P = 0.009). The sensitivities at 95% and 99% specificity were 85.4% and 76.0% (UNC OCT Index), 71.9% and 62.5% (VCDR, all P < 0.001), 64.6% and 53.1% (average RNFL, all P < 0.001), and 66.7% and 58.3% (minimum GCIPL, all P < 0.001), respectively. CONCLUSIONS: The findings confirm that the UNC OCT Index may provide improved diagnostic perforce over that of single OCT parameters and may be a good tool for detection of early glaucoma. TRANSLATIONAL RELEVANCE: The UNC OCT Index algorithm may be incorporated easily into routine clinical practice and be useful for detecting early glaucoma. The Association for Research in Vision and Ophthalmology 2018-04-03 /pmc/articles/PMC5886105/ /pubmed/29629238 http://dx.doi.org/10.1167/tvst.7.2.16 Text en Copyright 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Articles
Mwanza, Jean-Claude
Lee, Gary
Budenz, Donald L.
Warren, Joshua L.
Wall, Michael
Artes, Paul H.
Callan, Thomas M.
Flanagan, John G.
Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma
title Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma
title_full Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma
title_fullStr Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma
title_full_unstemmed Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma
title_short Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma
title_sort validation of the unc oct index for the diagnosis of early glaucoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886105/
https://www.ncbi.nlm.nih.gov/pubmed/29629238
http://dx.doi.org/10.1167/tvst.7.2.16
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