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High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors

BACKGROUND: Hodgkin lymphoma (HL) patients are at an increased risk of late adverse treatment effects. While published studies focussed on the risk of either subsequent malignant neoplasms (SMNs) or cardiovascular disease (CVD), we examined the combined burden from SMN and CVD. METHODS: In 2908 5-ye...

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Autores principales: de Vries, Simone, Schaapveld, Michael, van Nimwegen, Frederika A, Jóźwiak, Katarzyna, Lugtenburg, Pieternella J, Daniëls, Laurien A, Roesink, Judith M, van der Maazen, Richard W M, Kok, Wouter E M, Aleman, Berthe M P, van Leeuwen, Flora E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886118/
https://www.ncbi.nlm.nih.gov/pubmed/29381685
http://dx.doi.org/10.1038/bjc.2017.476
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author de Vries, Simone
Schaapveld, Michael
van Nimwegen, Frederika A
Jóźwiak, Katarzyna
Lugtenburg, Pieternella J
Daniëls, Laurien A
Roesink, Judith M
van der Maazen, Richard W M
Kok, Wouter E M
Aleman, Berthe M P
van Leeuwen, Flora E
author_facet de Vries, Simone
Schaapveld, Michael
van Nimwegen, Frederika A
Jóźwiak, Katarzyna
Lugtenburg, Pieternella J
Daniëls, Laurien A
Roesink, Judith M
van der Maazen, Richard W M
Kok, Wouter E M
Aleman, Berthe M P
van Leeuwen, Flora E
author_sort de Vries, Simone
collection PubMed
description BACKGROUND: Hodgkin lymphoma (HL) patients are at an increased risk of late adverse treatment effects. While published studies focussed on the risk of either subsequent malignant neoplasms (SMNs) or cardiovascular disease (CVD), we examined the combined burden from SMN and CVD. METHODS: In 2908 5-year HL survivors treated between 1965 and 2000, the burden from SMN and/or CVD was assessed using cumulative incidences (CIs) and the mean cumulative count (MCC). RESULTS: We identified 888 SMNs and 1153 CVDs in 1247 patients (median follow-up 22 years). At 40 years, the CI for developing either SMN or CVD was 68% and the CI for developing both SMN and CVD was 17%, and an average of 1.2 events per patient (MCC) was observed. HL patients who developed a solid malignancy had similar 15-year risks to develop another subsequent malignancy or CVD (15%), whereas patients who developed a CVD after HL had a higher 15-year risk to develop another CVD compared with a subsequent malignancy (46 vs 15%). Radiotherapy was the strongest risk factor for developing both SMN and CVD in multivariable Cox regression models. CONCLUSIONS: Treating physicians should be aware of the increased risk of both SMN and CVD in patients treated for HL until 2000.
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spelling pubmed-58861182019-03-20 High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors de Vries, Simone Schaapveld, Michael van Nimwegen, Frederika A Jóźwiak, Katarzyna Lugtenburg, Pieternella J Daniëls, Laurien A Roesink, Judith M van der Maazen, Richard W M Kok, Wouter E M Aleman, Berthe M P van Leeuwen, Flora E Br J Cancer Epidemiology BACKGROUND: Hodgkin lymphoma (HL) patients are at an increased risk of late adverse treatment effects. While published studies focussed on the risk of either subsequent malignant neoplasms (SMNs) or cardiovascular disease (CVD), we examined the combined burden from SMN and CVD. METHODS: In 2908 5-year HL survivors treated between 1965 and 2000, the burden from SMN and/or CVD was assessed using cumulative incidences (CIs) and the mean cumulative count (MCC). RESULTS: We identified 888 SMNs and 1153 CVDs in 1247 patients (median follow-up 22 years). At 40 years, the CI for developing either SMN or CVD was 68% and the CI for developing both SMN and CVD was 17%, and an average of 1.2 events per patient (MCC) was observed. HL patients who developed a solid malignancy had similar 15-year risks to develop another subsequent malignancy or CVD (15%), whereas patients who developed a CVD after HL had a higher 15-year risk to develop another CVD compared with a subsequent malignancy (46 vs 15%). Radiotherapy was the strongest risk factor for developing both SMN and CVD in multivariable Cox regression models. CONCLUSIONS: Treating physicians should be aware of the increased risk of both SMN and CVD in patients treated for HL until 2000. Nature Publishing Group 2018-03-20 2018-01-30 /pmc/articles/PMC5886118/ /pubmed/29381685 http://dx.doi.org/10.1038/bjc.2017.476 Text en Copyright © 2018 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Epidemiology
de Vries, Simone
Schaapveld, Michael
van Nimwegen, Frederika A
Jóźwiak, Katarzyna
Lugtenburg, Pieternella J
Daniëls, Laurien A
Roesink, Judith M
van der Maazen, Richard W M
Kok, Wouter E M
Aleman, Berthe M P
van Leeuwen, Flora E
High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors
title High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors
title_full High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors
title_fullStr High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors
title_full_unstemmed High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors
title_short High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors
title_sort high burden of subsequent malignant neoplasms and cardiovascular disease in long-term hodgkin lymphoma survivors
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886118/
https://www.ncbi.nlm.nih.gov/pubmed/29381685
http://dx.doi.org/10.1038/bjc.2017.476
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