Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels

Defective axonal transport is an early neuropathological feature of amyotrophic lateral sclerosis (ALS). We have previously shown that ALS-associated mutations in Cu/Zn superoxide dismutase 1 (SOD1) impair axonal transport of mitochondria in motor neurons isolated from SOD1 G93A transgenic mice and...

Descripción completa

Detalles Bibliográficos
Autores principales: Moller, Annekathrin, Bauer, Claudia S, Cohen, Rebecca N, Webster, Christopher P, De Vos, Kurt J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886184/
https://www.ncbi.nlm.nih.gov/pubmed/28973175
http://dx.doi.org/10.1093/hmg/ddx348

Ejemplares similares

Ejemplares similares