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Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice

The Dlk1-Dio3 imprinted domain functions in embryonic development but the roles of noncoding RNAs expressed from this domain remain unclear. We addressed this question by generating transgenic (TG) mice harbouring a BAC carrying IG-DMR (intergenic-differentially methylated region), Gtl2-DMR, Gtl2, R...

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Detalles Bibliográficos
Autores principales:	Kumamoto, Soichiro, Takahashi, Nozomi, Nomura, Kayo, Fujiwara, Makoto, Kijioka, Megumi, Uno, Yoshinobu, Matsuda, Yoichi, Sotomaru, Yusuke, Kono, Tomohiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886287/ https://www.ncbi.nlm.nih.gov/pubmed/28934383 http://dx.doi.org/10.1093/hmg/ddx223

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