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An optimised multi-arm multi-stage clinical trial design for unknown variance
Multi-arm multi-stage trial designs can bring notable gains in efficiency to the drug development process. However, for normally distributed endpoints, the determination of a design typically depends on the assumption that the patient variance in response is known. In practice, this will not usually...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886309/ https://www.ncbi.nlm.nih.gov/pubmed/29474933 http://dx.doi.org/10.1016/j.cct.2018.02.011 |