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Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference

Multiple genetic studies have linked copy number variation (CNV) in different genes to body mass index (BMI) and obesity. A CNV on chromosome 10q11.22 has been associated with body weight. This CNV region spans NPY4R, the gene encoding the pancreatic polypeptide receptor Y4, which has been described...

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Autores principales: Shebanits, Kateryna, Andersson-Assarsson, Johanna C., Larsson, Ingrid, Carlsson, Lena M. S., Feuk, Lars, Larhammar, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886410/
https://www.ncbi.nlm.nih.gov/pubmed/29621259
http://dx.doi.org/10.1371/journal.pone.0194668
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author Shebanits, Kateryna
Andersson-Assarsson, Johanna C.
Larsson, Ingrid
Carlsson, Lena M. S.
Feuk, Lars
Larhammar, Dan
author_facet Shebanits, Kateryna
Andersson-Assarsson, Johanna C.
Larsson, Ingrid
Carlsson, Lena M. S.
Feuk, Lars
Larhammar, Dan
author_sort Shebanits, Kateryna
collection PubMed
description Multiple genetic studies have linked copy number variation (CNV) in different genes to body mass index (BMI) and obesity. A CNV on chromosome 10q11.22 has been associated with body weight. This CNV region spans NPY4R, the gene encoding the pancreatic polypeptide receptor Y4, which has been described as a satiety-stimulating receptor. We have investigated CNV of the NPY4R gene and analysed its relationship to BMI, waist circumference and self-reported dietary intake from 558 individuals (216 men and 342 women) representing a wide BMI range. The copy number for NPY4R ranged from 2 to 8 copies (average 4.6±0.8). Rather than the expected negative correlation, we observed a positive correlation between NPY4R copy number and BMI as well as waist circumference in women (Pearson’s r = 0.267, p = 2.65×10(−7) and r = 0.256, p = 8×10(−7), respectively). Each additional copy of NPY4R correlated with 2.6 kg/m(2) increase in BMI and 5.67 cm increase in waist circumference (p = 2.8×10(−5) and p = 6.2×10(−5), respectively) for women. For men, there was no statistically significant correlation between CNV and BMI. Our results suggest that NPY4R genetic variation influences body weight in women, but the exact role of this receptor appears to be more complex than previously proposed.
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spelling pubmed-58864102018-04-20 Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference Shebanits, Kateryna Andersson-Assarsson, Johanna C. Larsson, Ingrid Carlsson, Lena M. S. Feuk, Lars Larhammar, Dan PLoS One Research Article Multiple genetic studies have linked copy number variation (CNV) in different genes to body mass index (BMI) and obesity. A CNV on chromosome 10q11.22 has been associated with body weight. This CNV region spans NPY4R, the gene encoding the pancreatic polypeptide receptor Y4, which has been described as a satiety-stimulating receptor. We have investigated CNV of the NPY4R gene and analysed its relationship to BMI, waist circumference and self-reported dietary intake from 558 individuals (216 men and 342 women) representing a wide BMI range. The copy number for NPY4R ranged from 2 to 8 copies (average 4.6±0.8). Rather than the expected negative correlation, we observed a positive correlation between NPY4R copy number and BMI as well as waist circumference in women (Pearson’s r = 0.267, p = 2.65×10(−7) and r = 0.256, p = 8×10(−7), respectively). Each additional copy of NPY4R correlated with 2.6 kg/m(2) increase in BMI and 5.67 cm increase in waist circumference (p = 2.8×10(−5) and p = 6.2×10(−5), respectively) for women. For men, there was no statistically significant correlation between CNV and BMI. Our results suggest that NPY4R genetic variation influences body weight in women, but the exact role of this receptor appears to be more complex than previously proposed. Public Library of Science 2018-04-05 /pmc/articles/PMC5886410/ /pubmed/29621259 http://dx.doi.org/10.1371/journal.pone.0194668 Text en © 2018 Shebanits et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shebanits, Kateryna
Andersson-Assarsson, Johanna C.
Larsson, Ingrid
Carlsson, Lena M. S.
Feuk, Lars
Larhammar, Dan
Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference
title Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference
title_full Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference
title_fullStr Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference
title_full_unstemmed Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference
title_short Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference
title_sort copy number of pancreatic polypeptide receptor gene npy4r correlates with body mass index and waist circumference
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886410/
https://www.ncbi.nlm.nih.gov/pubmed/29621259
http://dx.doi.org/10.1371/journal.pone.0194668
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