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Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence

Hepatitis B infection caused by the hepatitis B virus. It is one of the serious viral infection and a global health problem. In the transmission of hepatitis B infection different phases, i.e., acute and chronic carrier stages play an important role. The chronic carries individuals do not exhibit an...

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Autores principales: Khan, Tahir, Zaman, Gul, Saleh Alshomrani, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886416/
https://www.ncbi.nlm.nih.gov/pubmed/29621241
http://dx.doi.org/10.1371/journal.pone.0191914
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author Khan, Tahir
Zaman, Gul
Saleh Alshomrani, Ali
author_facet Khan, Tahir
Zaman, Gul
Saleh Alshomrani, Ali
author_sort Khan, Tahir
collection PubMed
description Hepatitis B infection caused by the hepatitis B virus. It is one of the serious viral infection and a global health problem. In the transmission of hepatitis B infection different phases, i.e., acute and chronic carrier stages play an important role. The chronic carries individuals do not exhibit any symptoms and are able to transmit the infection. Here we assessed the transmissibility associated with different infection stages of hepatitis B and generated an epidemic model with nonlinear incidence rate. In order to do this, first we formulate the model by splitting the infectious class into two subclasses, namely acutely infected and chronic carries with both horizontal and vertical transmission. The basic properties of the proposed model are presented. The basic reproductive number is obtained by using the next generation matrix approach. Biological sense of the threshold condition is investigated and discussed in detail. We also find the conditions to investigate all possible equilibria of the model in terms of the basic reproduction number. Finally, we perform numerical simulations to support our analytical work.
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spelling pubmed-58864162018-04-20 Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence Khan, Tahir Zaman, Gul Saleh Alshomrani, Ali PLoS One Research Article Hepatitis B infection caused by the hepatitis B virus. It is one of the serious viral infection and a global health problem. In the transmission of hepatitis B infection different phases, i.e., acute and chronic carrier stages play an important role. The chronic carries individuals do not exhibit any symptoms and are able to transmit the infection. Here we assessed the transmissibility associated with different infection stages of hepatitis B and generated an epidemic model with nonlinear incidence rate. In order to do this, first we formulate the model by splitting the infectious class into two subclasses, namely acutely infected and chronic carries with both horizontal and vertical transmission. The basic properties of the proposed model are presented. The basic reproductive number is obtained by using the next generation matrix approach. Biological sense of the threshold condition is investigated and discussed in detail. We also find the conditions to investigate all possible equilibria of the model in terms of the basic reproduction number. Finally, we perform numerical simulations to support our analytical work. Public Library of Science 2018-04-05 /pmc/articles/PMC5886416/ /pubmed/29621241 http://dx.doi.org/10.1371/journal.pone.0191914 Text en © 2018 Khan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Khan, Tahir
Zaman, Gul
Saleh Alshomrani, Ali
Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence
title Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence
title_full Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence
title_fullStr Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence
title_full_unstemmed Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence
title_short Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence
title_sort spreading dynamic of acute and carrier hepatitis b with nonlinear incidence
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886416/
https://www.ncbi.nlm.nih.gov/pubmed/29621241
http://dx.doi.org/10.1371/journal.pone.0191914
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