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Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence
Hepatitis B infection caused by the hepatitis B virus. It is one of the serious viral infection and a global health problem. In the transmission of hepatitis B infection different phases, i.e., acute and chronic carrier stages play an important role. The chronic carries individuals do not exhibit an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886416/ https://www.ncbi.nlm.nih.gov/pubmed/29621241 http://dx.doi.org/10.1371/journal.pone.0191914 |
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author | Khan, Tahir Zaman, Gul Saleh Alshomrani, Ali |
author_facet | Khan, Tahir Zaman, Gul Saleh Alshomrani, Ali |
author_sort | Khan, Tahir |
collection | PubMed |
description | Hepatitis B infection caused by the hepatitis B virus. It is one of the serious viral infection and a global health problem. In the transmission of hepatitis B infection different phases, i.e., acute and chronic carrier stages play an important role. The chronic carries individuals do not exhibit any symptoms and are able to transmit the infection. Here we assessed the transmissibility associated with different infection stages of hepatitis B and generated an epidemic model with nonlinear incidence rate. In order to do this, first we formulate the model by splitting the infectious class into two subclasses, namely acutely infected and chronic carries with both horizontal and vertical transmission. The basic properties of the proposed model are presented. The basic reproductive number is obtained by using the next generation matrix approach. Biological sense of the threshold condition is investigated and discussed in detail. We also find the conditions to investigate all possible equilibria of the model in terms of the basic reproduction number. Finally, we perform numerical simulations to support our analytical work. |
format | Online Article Text |
id | pubmed-5886416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58864162018-04-20 Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence Khan, Tahir Zaman, Gul Saleh Alshomrani, Ali PLoS One Research Article Hepatitis B infection caused by the hepatitis B virus. It is one of the serious viral infection and a global health problem. In the transmission of hepatitis B infection different phases, i.e., acute and chronic carrier stages play an important role. The chronic carries individuals do not exhibit any symptoms and are able to transmit the infection. Here we assessed the transmissibility associated with different infection stages of hepatitis B and generated an epidemic model with nonlinear incidence rate. In order to do this, first we formulate the model by splitting the infectious class into two subclasses, namely acutely infected and chronic carries with both horizontal and vertical transmission. The basic properties of the proposed model are presented. The basic reproductive number is obtained by using the next generation matrix approach. Biological sense of the threshold condition is investigated and discussed in detail. We also find the conditions to investigate all possible equilibria of the model in terms of the basic reproduction number. Finally, we perform numerical simulations to support our analytical work. Public Library of Science 2018-04-05 /pmc/articles/PMC5886416/ /pubmed/29621241 http://dx.doi.org/10.1371/journal.pone.0191914 Text en © 2018 Khan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Khan, Tahir Zaman, Gul Saleh Alshomrani, Ali Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence |
title | Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence |
title_full | Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence |
title_fullStr | Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence |
title_full_unstemmed | Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence |
title_short | Spreading dynamic of acute and carrier hepatitis B with nonlinear incidence |
title_sort | spreading dynamic of acute and carrier hepatitis b with nonlinear incidence |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886416/ https://www.ncbi.nlm.nih.gov/pubmed/29621241 http://dx.doi.org/10.1371/journal.pone.0191914 |
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