Pathways to understanding the genomic aetiology of osteoarthritis

Osteoarthritis is a common, complex disease with no curative therapy. In this review, we summarize current knowledge on disease aetiopathogenesis and outline genetics and genomics approaches that are helping catalyse a much-needed improved understanding of the biological underpinning of disease deve...

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Detalles Bibliográficos
Autores principales: Cibrián Uhalte, Elena, Wilkinson, Jeremy Mark, Southam, Lorraine, Zeggini, Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Invited Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886472/
https://www.ncbi.nlm.nih.gov/pubmed/28977450
http://dx.doi.org/10.1093/hmg/ddx302
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author Cibrián Uhalte, Elena
Wilkinson, Jeremy Mark
Southam, Lorraine
Zeggini, Eleftheria
author_facet Cibrián Uhalte, Elena
Wilkinson, Jeremy Mark
Southam, Lorraine
Zeggini, Eleftheria
author_sort Cibrián Uhalte, Elena
collection PubMed
description Osteoarthritis is a common, complex disease with no curative therapy. In this review, we summarize current knowledge on disease aetiopathogenesis and outline genetics and genomics approaches that are helping catalyse a much-needed improved understanding of the biological underpinning of disease development and progression.
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spelling pubmed-58864722018-04-09 Pathways to understanding the genomic aetiology of osteoarthritis Cibrián Uhalte, Elena Wilkinson, Jeremy Mark Southam, Lorraine Zeggini, Eleftheria Hum Mol Genet Invited Reviews Osteoarthritis is a common, complex disease with no curative therapy. In this review, we summarize current knowledge on disease aetiopathogenesis and outline genetics and genomics approaches that are helping catalyse a much-needed improved understanding of the biological underpinning of disease development and progression. Oxford University Press 2017-10-01 2017-07-27 /pmc/articles/PMC5886472/ /pubmed/28977450 http://dx.doi.org/10.1093/hmg/ddx302 Text en © The Author 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Reviews
Cibrián Uhalte, Elena
Wilkinson, Jeremy Mark
Southam, Lorraine
Zeggini, Eleftheria
Pathways to understanding the genomic aetiology of osteoarthritis
title Pathways to understanding the genomic aetiology of osteoarthritis
title_full Pathways to understanding the genomic aetiology of osteoarthritis
title_fullStr Pathways to understanding the genomic aetiology of osteoarthritis
title_full_unstemmed Pathways to understanding the genomic aetiology of osteoarthritis
title_short Pathways to understanding the genomic aetiology of osteoarthritis
title_sort pathways to understanding the genomic aetiology of osteoarthritis
topic Invited Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886472/
https://www.ncbi.nlm.nih.gov/pubmed/28977450
http://dx.doi.org/10.1093/hmg/ddx302
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AT zegginieleftheria pathwaystounderstandingthegenomicaetiologyofosteoarthritis

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