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Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter

Spirometry has been used as the main strategy for assessing ventilatory changes related to occupational exposure to particulate matter (OEPM). However, in some cases, as one of its limitations, it may not be sensitive enough to show abnormalities before extensive damage, as seen in restrictive lung...

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Autores principales: Chao, T.P., Sperandio, E.F., Ostolin, T.L.V.P., Almeida, V.R., Romiti, M., Gagliardi, A.R.T., Arantes, R.L., Dourado, V.Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886555/
https://www.ncbi.nlm.nih.gov/pubmed/29590255
http://dx.doi.org/10.1590/1414-431X20186486
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author Chao, T.P.
Sperandio, E.F.
Ostolin, T.L.V.P.
Almeida, V.R.
Romiti, M.
Gagliardi, A.R.T.
Arantes, R.L.
Dourado, V.Z.
author_facet Chao, T.P.
Sperandio, E.F.
Ostolin, T.L.V.P.
Almeida, V.R.
Romiti, M.
Gagliardi, A.R.T.
Arantes, R.L.
Dourado, V.Z.
author_sort Chao, T.P.
collection PubMed
description Spirometry has been used as the main strategy for assessing ventilatory changes related to occupational exposure to particulate matter (OEPM). However, in some cases, as one of its limitations, it may not be sensitive enough to show abnormalities before extensive damage, as seen in restrictive lung diseases. Therefore, we hypothesized that cardiopulmonary exercise testing (CPET) may be better than spirometry to detect early ventilatory impairment caused by OEPM. We selected 135 male workers with at least one year of exposure. After collection of self-reported socioeconomic status, educational level, and cardiovascular risk data, participants underwent spirometry, CPET, body composition assessment (bioelectrical impedance), and triaxial accelerometry (for level of physical activity in daily life). CPET was performed using a ramp protocol on a treadmill. Metabolic, cardiovascular, ventilatory, and submaximal relationships were measured. We compared 52 exposed to 83 non-exposed workers. Multiple linear regressions were developed using spirometry and CPET variables as outcomes and OEPM as the main predictor, and adjusted by the main covariates. Our results showed that OEPM was associated with significant reductions in peak minute ventilation, peak tidal volume, and breathing reserve index. Exposed participants presented shallower slope of ΔVT/ΔlnV̇E (breathing pattern), i.e., increased tachypneic breathing pattern. The OEPM explained 7.4% of the ΔVT/ΔlnV̇E variability. We found no significant influence of spirometric indices after multiple linear regressions. We conclude that CPET might be a more sensitive feature of assessing early pulmonary impairment related to OEPM. Our cross-sectional results suggested that CPET is a promising tool for the screening of asymptomatic male workers.
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spelling pubmed-58865552018-04-06 Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter Chao, T.P. Sperandio, E.F. Ostolin, T.L.V.P. Almeida, V.R. Romiti, M. Gagliardi, A.R.T. Arantes, R.L. Dourado, V.Z. Braz J Med Biol Res Research Articles Spirometry has been used as the main strategy for assessing ventilatory changes related to occupational exposure to particulate matter (OEPM). However, in some cases, as one of its limitations, it may not be sensitive enough to show abnormalities before extensive damage, as seen in restrictive lung diseases. Therefore, we hypothesized that cardiopulmonary exercise testing (CPET) may be better than spirometry to detect early ventilatory impairment caused by OEPM. We selected 135 male workers with at least one year of exposure. After collection of self-reported socioeconomic status, educational level, and cardiovascular risk data, participants underwent spirometry, CPET, body composition assessment (bioelectrical impedance), and triaxial accelerometry (for level of physical activity in daily life). CPET was performed using a ramp protocol on a treadmill. Metabolic, cardiovascular, ventilatory, and submaximal relationships were measured. We compared 52 exposed to 83 non-exposed workers. Multiple linear regressions were developed using spirometry and CPET variables as outcomes and OEPM as the main predictor, and adjusted by the main covariates. Our results showed that OEPM was associated with significant reductions in peak minute ventilation, peak tidal volume, and breathing reserve index. Exposed participants presented shallower slope of ΔVT/ΔlnV̇E (breathing pattern), i.e., increased tachypneic breathing pattern. The OEPM explained 7.4% of the ΔVT/ΔlnV̇E variability. We found no significant influence of spirometric indices after multiple linear regressions. We conclude that CPET might be a more sensitive feature of assessing early pulmonary impairment related to OEPM. Our cross-sectional results suggested that CPET is a promising tool for the screening of asymptomatic male workers. Associação Brasileira de Divulgação Científica 2018-03-26 /pmc/articles/PMC5886555/ /pubmed/29590255 http://dx.doi.org/10.1590/1414-431X20186486 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Chao, T.P.
Sperandio, E.F.
Ostolin, T.L.V.P.
Almeida, V.R.
Romiti, M.
Gagliardi, A.R.T.
Arantes, R.L.
Dourado, V.Z.
Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter
title Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter
title_full Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter
title_fullStr Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter
title_full_unstemmed Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter
title_short Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter
title_sort use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886555/
https://www.ncbi.nlm.nih.gov/pubmed/29590255
http://dx.doi.org/10.1590/1414-431X20186486
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